SUN1 Is Required for Telomere Attachment to Nuclear Envelope and Gametogenesis in Mice

Ding, Xu; Xu, Rener; Yu, Juehua; Xu, Tian; Zhuang, Yuan; Han, Min

doi:10.1016/j.devcel.2007.03.018

Cited by 368 publications

(465 citation statements)

References 42 publications

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“…Telomere-mediated movement along the nuclear envelope is crucial for homologous pairing and synapsis during meiosis (108). Meiotic telomeres carry a set of specific proteins such as SUN1, SUN2 and TERB1, which associate with telomeres between the leptotene and diplotene stages during meiotic prophase I (109,110). The telomere fusion during meiosis in our study could be associated with altered function of these telomere-associated proteins.…”

Section: Discussionmentioning

confidence: 99%

Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice

et al. 2016

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The epigenetic events imposed during germline reprogramming and affected by harmful exposure can be inherited and transferred to subsequent generations via gametes inheritance. In this study, we examine the transgenerational effects promoted by widely used herbicide atrazine (ATZ). We exposed pregnant outbred CD1 female mice and the male progeny was crossed for three generations with untreated females. We demonstrate here that exposure to ATZ affects meiosis, spermiogenesis and reduces the spermatozoa number in the third generation (F3) male mice. We suggest that changes in testis cell types originate from modified transcriptional network in undifferentiated spermatogonia. Importantly, exposure to ATZ dramatically increases the number of transcripts with novel transcription initiation sites, spliced variants and alternative polyadenylation sites. We found the global decrease in H3K4me3 occupancy in the third generation males. The regions with altered H3K4me3 occupancy in F3 ATZ-derived males correspond to altered H3K4me3 occupancy of F1 generation and 74% of changed peaks in F3 generation are associated with enhancers. The regions with altered H3K4me3 occupancy are enriched in SP family and WT1 transcription factor binding sites. Our data suggest that the embryonic exposure to ATZ affects the development and the changes induced by ATZ are transferred up to three generations.

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Section: Discussionmentioning

confidence: 99%

Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice

et al. 2016

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“…A crucial event promoting homolog synapsis is telomeremediated chromosome movement and the bouquet configuration of chromosomes, a process that depends on the NE proteins SUN/KASH and is disrupted in Sun1 knockout mice (Ding et al 2007). We examined the effect of Sun1 knockout on the process of homolog pairing.…”

Section: Homolog Association In Sun1 Knockoutmentioning

confidence: 99%

“…Arguably, chromosome movement that may promote alignment is thought to be crucial for homolog pairing (Voet et al 2003;Lee et al 2012;Boateng et al 2013;Lui et al 2013); however, it has been reported that 22%;25% of zygotenearrested Sun1 knockout spermatocytes form synapses (Ding et al 2007). Sun1 knockout spermatocytes lack overall chromosome movement (Shibuya et al 2014) but retain the ability to undergo homolog pairing (Fig.…”

Section: Telomere-driven Chromosome Movement Is Not Essential For Hommentioning

confidence: 99%

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Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes

Ishiguro¹,

et al. 2014

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During meiosis, homologous chromosome (homolog) pairing is promoted by several layers of regulation that include dynamic chromosome movement and meiotic recombination. However, the way in which homologs recognize each other remains a fundamental issue in chromosome biology. Here, we show that homolog recognition or association initiates upon entry into meiotic prophase before axis assembly and double-strand break (DSB) formation. This homolog association develops into tight pairing only during or after axis formation. Intriguingly, the ability to recognize homologs is retained in Sun1 knockout spermatocytes, in which telomere-directed chromosome movement is abolished, and this is the case even in Spo11 knockout spermatocytes, in which DSB-dependent DNA homology search is absent. Disruption of meiosis-specific cohesin RAD21L precludes the initial association of homologs as well as the subsequent pairing in spermatocytes. These findings suggest the intriguing possibility that homolog recognition is achieved primarily by searching for homology in the chromosome architecture as defined by meiosis-specific cohesin rather than in the DNA sequence itself.

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“…34 Likewise, meiotic bouquet formation also requires Sun1 and Sun2 in mammalian cells. 35,36 The interactions between yeast Mps3 and telomeres is likely to be mediated by a direct interaction with the Est1 component of the telomerase machinery. 37 Similarly, interactions between Mps3 and the telomerase machinery appear likely to regulate DSB localization to the periphery.…”

Section: Introductionmentioning

confidence: 99%

Opening the DNA repair toolbox: Localization of DNA double strand breaks to the nuclear periphery

Oza¹,

Peterson²

2010

Cell Cycle

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E fficient repair of DNA double strand breaks is essential for cells to avoid increased mutation rates, genomic instability, and even cell death. Consequently, cells have evolved multiple mechanisms for rapidly repairing these DNA lesions, including error-free homologous recombination as well as error-prone pathways such as nonhomologous end joining. What happens to DSBs that are repaired inefficiently or not at all? Recently, several studies in budding yeast have shown that these more recalcitrant DSBs are localized to the nuclear periphery through interactions between the nuclear envelope protein, Mps3, and proteins associated with DSB chromatin. Why these DSBs are tethered to the nuclear periphery is still not clear, though the current view is that alternative repair pathways may be activated at the periphery in a final attempt to repair the lesion. In this Extra View, we discuss these recent reports, and we show that the Est1 component of the telomerase machinery plays an essential role in anchoring DSB chromatin to the nuclear envelope protein, Mps3.

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SUN1 Is Required for Telomere Attachment to Nuclear Envelope and Gametogenesis in Mice

Cited by 368 publications

References 42 publications

Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice

Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice

Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes

Opening the DNA repair toolbox: Localization of DNA double strand breaks to the nuclear periphery

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