Sun exposure and melanocytic naevi in young Australian children

Harrison, Simone L.; Speare, Rick; Wronski, Ian; MacLennan, Robert

doi:10.1016/s0140-6736(94)90348-4

Cited by 185 publications

(144 citation statements)

References 24 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…18,19 Nevertheless, the relationship between sunlight exposure and the risk of cutaneous melanoma is well documented, 20 and many reports have also shown an association between sunlight and the induction of cutaneous melanocytic naevi. 21,22 The distribution of solar light on the retinal sphere may therefore account for the topographical fundus distribution of choroidal naevi found in this as well as in other studies, and we believe that this is the first study to ascertain this possibility. The mean naevus diameter of 3.2 mm in our series is in accordance with earlier studies.…”

Section: Discussionsupporting

confidence: 65%

Topographical distribution of choroidal naevi in the ocular fundus

Krohn

Frøystein

Dahl

2008

Eye

View full text Add to dashboard Cite

Objective To analyse the topographical distribution of choroidal naevi and to visualise their location in the ocular fundus. Methods Data on the size and location of 210 choroidal naevi were converted into a database of two-dimensional retinal charts by means of computer-drawing software. The geometric centre of each lesion was entered into corresponding sectors of the retinal chart. The location of the naevi was computationally visualised by merging the fundus drawings and displaying the number of overlapping lesions on colour-coded contour maps. Results Five naevi were located exactly between two fundus sectors, and were therefore excluded from the distribution analysis. Ten naevi (5%) were located anterior and 195 (95%) posterior to the equator. A total of 104 naevi (51%) were located in the temporal and 101 (49%) in the nasal hemisphere, and the distribution between the superior and inferior hemisphere was 104 (51%) and 101 (49%), respectively. The distribution did not differ significantly between genders, age groups, or between right and left eyes. More naevi with a diameter of 43 mm were located in the temporal hemisphere (P ¼ 0.0004) and anterior to the equator (P ¼ 0.006) compared with those with a diameter of p3 mm. A similar distribution was found for naevi with overlying drusen. Conclusions Choroidal naevi are uniformly concentrated in the centre of the posterior pole without any significant nasotemporal or superoinferior asymmetry. However, large naevi occur significantly more often in the temporal hemisphere and more anteriorly compared with small lesions.

show abstract

Section: Discussionsupporting

confidence: 65%

Topographical distribution of choroidal naevi in the ocular fundus

Krohn

Frøystein

Dahl

2008

Eye

View full text Add to dashboard Cite

show abstract

“…Naevus count studies have shown that UVR exposure probably influences the expression of the naevus phenotype in children (Fritschi et al, 1994;Harrison et al 1994;Kelly et al, 1994), but this has not been formally shown in adults. The importance of genetic factors in the induction of naevi has been demonstrated in studies on familial melanoma and the AMS with an autosomal dominant pattern of inheritance (Cannon-Albright et al, 1992;McGeogh et al, 1994;Newton et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of melanoma in Australia is thought to be attributable to high levels of sun exposure, but it is not entirely clear to what extent exposure to ultraviolet radiation affects the development of common and atypical naevi. Kelly et al (1994) reported that children from Queensland, Australia, had higher numbers of naevi than children from Victoria (the latter being further away from the equator), and other studies in children have also suggested that sun exposure early in life induces naevi (Holman and Armstrong, 1984b;Fritschi et al, 1994;Harrison et al, 1994). In adults, there have been no formal studies looking at the difference in naevus phenotype in countries with different exposure patterns.…”

mentioning

confidence: 99%

The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia

Bataille¹,

Grulich²,

Sasieni³

et al. 1998

Br J Cancer

101

View full text Add to dashboard Cite

Summary Two case-control studies were set up to investigate the relationship between melanocytic naevi and risk of melanoma and to compare the naevus phenotype in two countries exposed to greatly different levels of sun exposure and different melanoma rates. In England 117 melanoma cases and 163 controls were recruited from the North-East Thames Region and 183 melanoma cases and 162 controls from New South Wales, Australia. Each subject underwent a whole-body naevus count performed by the same examiner in each country. Relative risks associated with melanocytic naevi in each country were calculated with comparison of naevus data in controls between Australia and England. Atypical naevi were strong risk factors for melanoma in both countries: the odds ratio (OR) for three or more atypical naevi was 4.6 (95% Cl 2.0-10.7) in Australia compared with 51.7 (95% Cl 6.5-408.4) in England. Common naevi were also significant risk factors in Australia and England with similar odds ratios in the two countries. Prevalence of atypical naevi was greater in Australian controls than in English controls: OR 9.7 (95% Cl 1.2-81.7) for three or more atypical naevi in Australia compared with England. For young age groups, the median number of common naevi was greater in Australia than in the UK, whereas for older individuals this difference in naevi number between the two countries disappeared. The prevalence of naevi on non-sun-exposed sites in controls was not significantly different between the two countries. The atypical mole syndrome (AMS) phenotype was more prevalent in Australian controls (6%) than in English controls (2%). The results of this study support the role of sun exposure in the induction of atypical naevi in adults. There was a trend towards stronger risk factors associated with atypical naevi in England compared with Australia. The atypical mole syndrome, usually associated with a genetic susceptibility to melanoma, was more common in Australia than in England, suggesting genetic environmental interactions with the possibility of phenocopies induced by sunlight.

show abstract

“…A study of Australian children found that increased sun exposure in childhood was significantly associated with an increased number of nevi [97]. A separate study of German adults found that intense, intermittent sun exposure in childhood or adolescence, characterized by sunburn, was significantly associated with high nevus counts and the occurrence of atypical nevi [77].…”

Section: Host Factorsmentioning

confidence: 99%

Melanoma Epidemiology and Prevention

Berwick

Buller

Cust

et al. 2015

Cancer Treatment and Research

122

121

View full text Add to dashboard Cite

The epidemiology of melanoma is complex, and individual risk depends on sun exposure, host factors, and genetic factors, and in their interactions as well. Sun exposure can be classified as intermittent, chronic, or cumulative (overall) exposure, and each appears to have a different effect on type of melanoma. Other environmental factors, such as chemical exposures-either through occupation, atmosphere, or food-may increase risk for melanoma, and this area warrants further study. Host factors that are well known to be important are the numbers and types of nevi and the skin phenotype. Genetic factors are classified as

show abstract

Sun exposure and melanocytic naevi in young Australian children

Cited by 185 publications

References 24 publications

Topographical distribution of choroidal naevi in the ocular fundus

Topographical distribution of choroidal naevi in the ocular fundus

The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia

Melanoma Epidemiology and Prevention

Contact Info

Product

Resources

About