Abstract:Introduction: Diabetic kidney disease (DKD) develops in approximately 40% of patients who are diabetic and results in heavy economic burdens. In the present study, we hypothesized that latent TGF-b1 is able to protect against fibrosis and inflammation in diabetic kidney via latent TGF-b/Arkadia/Smad7 pathways. Methods: Type 1 diabetes was induced in keratin-5 promoter-driven TGF-b transgenic (Tg) mice with overexpression of latent TGF-b and wild-type (Wt) littermates by streptozotocin (STZ). Fasting blood gluc… Show more
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