Sun-034 Does Salivary Urea Nitrogen Dipstick Allow Pediatric Acute Injury Detection in Sub-Saharan Africa?

Abstract

The AUC value of a panel of four biomarker candidates were higher than single biomarkers that reflects the value of simultaneous measurement of these four metabolite candidates than single candidates. Table 2 shows the list of diagnostic metabolite candidates with p < 0.05 and FC > 1.2.Pathway characterization was used to better understanding of pathophysiology of CIN. Only "Histidine_ lysine_ phenylalanine, tyrosine, proline and tryptophan catabolism" pathway (p < 0.05) was significant and suggested as the most important disturbed pathway in CIN. Conclusions: Early detection of CIN, after using contrast can help better management of this complication. In this study, only after 4 hours passed from using contrast media a panel of metabolites were found in urine of patients who developed CIN. This is the first study to investigate urine metabolic profile using NMR-based metabolomics for early detection of CIN after coronary angiography. The use of this suggested panel might significantly improve clinical consequences of this harmful complication.