SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy
Xin Shi,
Xuening Dang,
Zhenyu Huang
et al.
Abstract:Pathological cardiac hypertrophy is the leading cause of heart failure and has an extremely complicated pathogenesis. TEA domain transcription factor 1 (TEAD1) is recognized as an important transcription factor that plays a key regulatory role in cardiovascular disease. This study aimed to explore the role of TEAD1 in cardiac hypertrophy and to clarify the regulatory role of small ubiquitin‐like modifier (SUMO)‐mediated modifications. First, the expression level of TEAD1 in patients with heart failure, mice, a… Show more
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