SUMO specific peptidase 1 decreases after induction treatment, and its reduction predicts lower disease risk, better treatment response, longer survival of acute myeloid leukemia

Liu, J.; Li, Yue; Zhang, Guangying

doi:10.1080/00365513.2023.2175237

Cited by 1 publication

(2 citation statements)

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“…Overexpressed SENP1 is found in leukemia, multiple myeloma (MM) and mantle cell lymphoma ( Ohbayashi et al, 2008 ; Xu et al, 2015 ; Wang FF. et al, 2016 ; Zhang et al, 2021 ; Niu et al, 2022 ; Liu J. et al, 2023 ). In conclusion, SENP1 might play an oncogenic role not only in solid tumor, but also in malignant tumor, which deserves further exploring about the specific mechanism.…”

Section: Introductionmentioning

confidence: 98%

“…In bladder cancer, the level of SENP1 in urine can detect tumor recurrence ( Brems-Eskildsen et al, 2010 ). In AML, SENP1 decreases after induction therapy and its reduction predicts low disease risk, favorable treatment response, and long survival ( Liu J. et al, 2023 ). Multivariate Cox regression analysis showed that SENP1 was an independent prognostic factors for the survival of NSCLC patients ( Mu et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Emerging role of SENP1 in tumorigenesis and cancer therapy

Lin,

Zhang,

et al. 2024

Front. Pharmacol.

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Acting as a cysteine protease, small ubiquitin-like modifier (SUMO)/sentrin-specific protease1 (SENP1) involved in multiple physiological and pathological processes through processing the precursor SUMO protein into mature form and deSUMOylating target protein. It has been reported that SENP1 is highly expressed and plays a carcinogenic role in various cancers. In this paper, we mainly explore the function and mechanism of SENP1 in tumor cell proliferation, apoptosis, invasion, metastasis, stemness, angiogenesis, metabolism and drug resistance. Furthermore, the research progress of SENP1 inhibitors for cancer treatment is introduced. This study aims to provide theoretical references for cancer therapy by targeting SENP1.

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