Summary report of the Standards, Options and Recommendations for the management of patients with non-small-cell lung carcinoma (2000)

Depierre, A; Lagrange, Jean‐Léon; Theobald, Serge; Astoul, Philippe; Baldeyrou, P; Bardet, É.; Bazelly, B; Bréchot, J.-M.; Breton, Jean-Luc; Douillard, Jean-Yves; Grivaux, M; Jacoulet, P.; Khalil, Antoine; Lemarié, É.; Martinet, Yves; Massard, Gilbert; Milleron, B.; Molina, Thierry Jo; Moro‐Sibilot, D.; Paesmans, Marianne; Pujol, Jean-Louis; Quoix, Élisabeth; Ranfaing, E; Rivière, Alain; Sancho‐Garnier, H.; Souquet, Pierre-Jean; Spaëth, Dominique; Stoebner-Delbarre, Anne; Thiberville, Luc; Touboul, E.; Vaylet, F.; Vergnon, Jean‐Michel; Westeel, Virginie

doi:10.1038/sj.bjc.6601083

Cited by 28 publications

(27 citation statements)

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“…In each case, normal alveolar walls served as positive internal control. All patients consented to treatment and were treated with thoracic surgery, radiation therapy and/or chemotherapy, in accordance with national and international guidelines (Depierre et al, 2003) after a multidisciplinary assessment of their disease.…”

Section: Methodsmentioning

confidence: 99%

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

et al. 2005

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This study investigated the relation between positive thyroid transcription factor 1 (TTF1) staining and survival of patients affected by primary adenocarcinoma (ADC) of the lung. Pathological tissue from consecutive ADC patients was collected from 2002 to 2004. The anti-TTF1 antibody (8G7G3/1, dilution of 1/200) was used. Thyroid transcription factor 1 staining was assessed for each tumour as positive or negative. Probability of survival was estimated by Kaplan -Meier and difference tested by log-rank test. A Cox's regression multivariate analysis was carried out. In all, 106 patients were studied (66% male, 69% PS0 -1, 83% with stage III or IV). Tumours expressed positive TTF1 staining in 66% of cases. Multivariate analysis demonstrated an independent lower risk of death for patients whose tumour expresses positive TTF1 staining (HR ¼ 0.51, 95% CI 0.30 -0.85; P ¼ 0.01) and higher grade of differentiation (HR ¼ 0.40, 95% CI 0.24 -0.68; P ¼ 0.001). In conclusion, positive TTF1 staining strongly and independently correlates with survival of patients with primary ADC of the lung.

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Section: Methodsmentioning

confidence: 99%

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

et al. 2005

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“…[14][15][16] Differences in prevalence of incidental fi ndings between primary care networks were quantifi ed. The independent contribution of a network to the dichotomous diagnostic outcome (presence or absence of 1 or more incidental fi ndings) was determined using multivariate regression analysis, including age, sex, and smoking behavior.…”

Section: Discussionmentioning

confidence: 99%

Incidental Chest Radiographic Findings in Adult Patients With Acute Cough

Vugt

Broekhuizen

Zuithoff

et al. 2012

The Annals of Family Medicine

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PURPOSE Imaging may produce unexpected or incidental fi ndings with consequences for patients and ordering of future investigations. Chest radiography in patients with acute cough is among the most common reasons for imaging in primary care, but data on associated incidental fi ndings are lacking. We set out to describe the type and prevalence of incidental chest radiography fi ndings in primary care patients with acute cough. METHODSWe report on data from a cross-sectional study in 16 European primary care networks on 3,105 patients with acute cough, all of whom were undergoing chest radiography as part of a research study workup. Apart from assessment for specifi ed signs of pneumonia and acute bronchitis, local radiologists were asked to evaluate any additional fi nding on the radiographs. For the 2,823 participants with good-quality chest radiographs, these fi ndings were categorized according to clinical relevance based on previous research evidence and analyzed for type and prevalence by network, sex, age, and smoking status. RESULTSIncidental fi ndings were reported in 19% of all participants, and ranged from 0% to 25% by primary care network, with the network being an independent contributor (P <.001). Of all participants 3% had clinically relevant incidental fi ndings. Suspected nodules and shadows were reported in 1.8%. Incidental fi ndings were more common is older participants and smokers (P <.001).CONCLUSIONS Clinically relevant incidental fi ndings on chest radiographs in primary care adult patients with acute cough are uncommon, and prevalence varies by setting. Ann Fam Med 2012;10:510-515. doi:10.1370/afm.1384. INTRODUCTIONA cute cough is one of the most common reasons for consulting in primary care. 1,2 Prompt, accurate diagnosis of pneumonia in these patients is important to rule in the need for timely appropriate antibiotic treatment in some patients and to rule out the need for antibiotic treatment in others. Responsible general practitioners order chest radiographs in a minority of patients with acute cough. 3 These radiographs confi rm pneumonia in 5% to 19% and exclude pneumonia in most patients. 2,4,5 Imaging provides information relevant to the acute illness but may also reveal incidental fi ndings. 6-9 Such fi ndings can benefi t patients through earlier diagnosis and treatment, for example, in as yet undiagnosed heart failure or malignancy. Incidental fi ndings, however, may have unknown or doubtful clinical relevance and lead to patient anxiety, expensive workup, and potentially harmful investigations and treatment without improving quality and length of life. 10,11 The nature and prevalence of incidental fi ndings on chest radiographs of patients who consult their general practitioner for acute cough is unknown. Such data may inform decisions about clinical indications for ordering chest radiographs. We studied incidental fi ndings on chest radiographs obtained METHODSWe undertook a cross-sectional observational study using data from the GRACE-09/10a study (Genomics to comba...

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“…Guidelines sponsored by several national professional organizations recommend routine surveillance of these patients with chest radiographic or chest CT imaging performed at specified intervals after resection (8)(9)(10)(13)(14)(15)(16)(17). These recommendations vary considerably and range from regularly scheduled clinic visits (15,17) with or without a chest radiograph at 3-to 6-month intervals (10) to a semiannual chest CT scan after the initial resection (9,14).…”

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Pattern of Imaging after Lung Cancer Resection. 1992–2005

Sharma

Nishi²,

Lin

et al. 2016

Annals ATS

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Rationale: Imaging intensity after lung cancer resection performed with curative intent is unknown.Objectives: To describe the pattern and trends in the use of computed tomography (CT) and positron emission tomography (PET) scans in patients after resection of early-stage lung cancer. Measurements and Main Results: Overall, imaging use was higher within the first 2 years versus Years 3-5 after surgical resection. Use of surveillance CT scans increased sharply from 13.7 to 57.3% of those diagnosed in 1996-1997 and 2004-2005, respectively. PET scan use increased threefold, from 6.2% in 2000-2001 to 19.6% in 2004-2005. In multivariable analyses, we observed a 32% increase in the odds of undergoing surveillance CT or PET imaging for every year of diagnosis between 1998 and 2005. There was no substantial decline in the odds of having a surveillance CT or PET scan during each successive follow-up period, suggesting no change in the intensity of surveillance over the first 5 years after surgical resection. The proportion of surveillance CT imaging performed at freestanding imaging centers increased from 18.0% in 1998-1999 to 30.6% in 2004-2005. Methods Conclusions:The use of CT and PET imaging for surveillance after curative-intent surgical resection of early-stage lung cancer increased sharply in the United States between 1997-1998 and 2005. In the absence of evidence demonstrating favorable outcomes, this practice was likely driven by prevailing expert opinion embedded in clinical practice guidelines made available during that time. Research is clearly needed to determine the role and optimal approach to surveillance thoracic imaging after surgical resection of lung cancer.

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Summary report of the Standards, Options and Recommendations for the management of patients with non-small-cell lung carcinoma (2000)

Cited by 28 publications

References 1 publication

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

Incidental Chest Radiographic Findings in Adult Patients With Acute Cough

Pattern of Imaging after Lung Cancer Resection. 1992–2005

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