Summary of the Scientific Conference on Dietary Fatty Acids and Cardiovascular Health

Kris‐Etherton, Penny M.; Daniels, Stephen R.; Eckel, Robert H.; Engler, Marguerite M.; Howard, Barbara V.; Krauss, Ronald M.; Lichtenstein, Alice H.; Sacks, Frank M.; Jeor, Sachiko St.; Stampfer, Meir J.; Grundy, Scott M.; Appel, Lawrence J.; Byers, Tim; Campos, Hannia; Cooney, Greg; Denke, Margo A.; Kennedy, Eileen; Marckmann, Peter; Pearson, Thomas A.; Riccardi, Gabriele; Rudel, Lawrence L.; Rudrum, Mike; Stein, Daniel T.; Tracy, Russell P.; Ursin, Virginia M.; Vogel, Robert A.; Zock, P.L.; Bazzarre, Terry L.; Clark, Julie

doi:10.1161/01.cir.103.7.1034

Cited by 124 publications

(63 citation statements)

References 25 publications

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“…Cholesterol lowering diets & supplements may allow therapeutic goals for LDLc to be reached without additional medication. 23 The available data support the hypothesis that oxidation of LDL by cells in the arterial wall is a pivotal step in the initiation of early lesions seen in coronary atherosclerosis. Thus, there has been a heightened interest in antioxidants which may work to prevent or retard this process.…”

Section: Introductionsupporting

confidence: 58%

Tocotrienols and its impact in cardiovascular health

Mishra

Badade²,

Lingidi³

et al. 2014

Int J Clin Trials

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Section: Introductionsupporting

confidence: 58%

Tocotrienols and its impact in cardiovascular health

Mishra

Badade²,

Lingidi³

et al. 2014

Int J Clin Trials

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“…The human body is unable to synthesize these fatty acids, while plants have the ability to synthesize C18:3n-3 acid de novo. Intensive efforts have therefore been made to improve the lipid/fatty acids profi le of fruits and vegetables, with high nutritional values in diets [Kris- Etherton et al, 2001].…”

Section: Resultsmentioning

confidence: 99%

Comparison of Nutrient Content in Fruit of Commercial Cultivars of Eggplant (Solanum melongena L.)

Ayaz

Çolak

Topuz

et al. 2015

Pol. J. Food Nutr. Sci.

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“…As the negative relationship between individual saturated fats and metabolic and CVD risk, and the positive relationship with individual omega 3 fats (Keys, 1980;Hu et al, 2001;Kris-Etherton et al, 2001) is well known, it is important to elucidate whether overall patterns of free fatty acid status, characterized by either high Fatty acid patterns and CVD risk PML Skidmore et al saturated fat or high omega 3 content, would result in similar relationships to CVD risk. We found that men in the highest category of CVD risk had more adverse levels of individual fatty acids.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulated evidence shows a strong link between intake of saturated fatty acids, hypercholesterolaemia and both cardiovascular disease (CVD) incidence and mortality (Keys, 1980;Hu et al, 2001;Kris-Etherton et al, 2001) and also on individual risk factors for the metabolic syndrome and CVD, such as high blood pressure and C-reactive protein (Madsen et al, 2001;Sacks and Katan, 2002;Pischon et al, 2003;KrisEtherton et al, 2005). Altering fat intake has been shown to result in changes in the fatty acid content of plasma phospholipid, cholesteryl ester and triacylgycerol fatty acids that reflect fatty acid intake over the short term (weeks to months).…”

Section: Introductionmentioning

confidence: 99%

Plasma free fatty acid patterns and their relationship with CVD risk in a male middle-aged population

et al. 2010

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Background/Objectives: The role of individual fatty acids in the development of cardiovascular disease (CVD) is well established, but the effects of an overall pattern of fatty acids in CVD risk has yet to be elucidated. Circulating fatty acid levels are related to metabolic disturbances associated with the metabolic syndrome and CVD, due to disturbances in the activity of enzymes that catalyse fatty acid desaturation (D-desaturases). Therefore, we determined patterns of fatty acids and estimated desaturase activity in plasma and analysed how these patterns were related to a 10-year CVD risk estimates in a middle-aged male population in Northern Ireland. Subjects/Methods: Principal components analysis (PCA) was performed for defining fatty acid patterns in 379 men aged 30-49 years. Logistic regression analyses were then carried out for analysing the relationship between these fatty acid patterns and the 10-year CVD risk estimates. Results: The PCA generated three high fatty acid patterns: high saturated fatty acid (SFA), high omega 3 fatty acid (omega 3) and high monosaturated fatty acid (MNFA). Results from logistic regression analyses show that a 1 s.d. increase in the SFA pattern score was significantly and positively associated with an increase in the 10-year CVD risk category (odds ratio 1.71, 95% confidence interval 1.33-2.21, Po0.0001) even after adjustment for lifestyle factors. There were no significant relationships between the other two pattern scores and the 10-year CVD risk. Conclusions: An unhealthy fatty acid pattern representing both dietary intake and in vivo fatty acid metabolism is related to the 10-year CVD risk estimates and provide evidence that, as with dietary patterns, the synergistic effect of multiple fatty acids may be more important in relation to the development of CVD risk.

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Summary of the Scientific Conference on Dietary Fatty Acids and Cardiovascular Health

Cited by 124 publications

References 25 publications

Tocotrienols and its impact in cardiovascular health

Tocotrienols and its impact in cardiovascular health

Comparison of Nutrient Content in Fruit of Commercial Cultivars of Eggplant (Solanum melongena L.)

Plasma free fatty acid patterns and their relationship with CVD risk in a male middle-aged population

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