Summary of the International Conference on Onco-Nephrology: an emerging field in medicine

Benigni, Ariella; Małyszko, Jolanta; Capasso, Giovambattista; Ariga, A.; Alahoti, Amit; Alexander, Todd; Altucci, Lucia; Amer, Hatem; Barone, Vincenzo; Benigni, Ariela; Biancone, Luigi; Bonventre, Joseph V.; Camussi, Giovanni; Capasso, Anna; Ciardiello, Fortunato; Capitanio, Umberto; Caraglia, Michele; Cartenì, Giacomo; Cervantes, Andrés; Citterio, Franco; Cosmai, Laura; Danesh, Farhad R.; Daniele, Bruno; D’Errico, Antonietta; Vita, Ferdinando De; Marzo, Vincenzo Di; Ereditato, A.; Falco, Geppino; Fouque, Denis; Franco, Renato; Gallieni, Maurizio; Gambaro, Giovanni; Gesualdo, Loreto; Grandaliano, Giuseppe; Kuo, Calvin J.; Jaimes, Edgar A.; Launay‐Vacher, Vincent; Maiello, Evaristo; Mallamaci, Francesca; Malysxko, Jolanta; Marino, Gloria E.; Martinelli, E.; Matarese, Giuseppe; Matsubara, Takeshi; Messa, Piergiorgio; Messina, Carlo; Mirone, Vincenzo; Morgillo, Floriana; Costa, Alessandro Nanni; Orditura, Michele; Pani, Antonello; Perazella, Mark A.; Perna, Alessandra; Pisano, Claudio; Pitts, Todd M.; Porta, Camillo; Procopio, Giuseppe; Qian, Qi; Remuzzi, Giuseppe; Ronco, Pierre; Rosner, Mitchell H.; Russo, Domenico; Siu, L.L.; Stadler, Walter M.; Trepiccione, Francesco; Troiani, Teresa; Viggiano, Davide; Weisz, Alessandro; Wiȩcek, Andrzej; Ding, Xiaoqiang; Zecchino, Ortensio; Zoccali, Carmine

doi:10.1016/j.kint.2019.04.043

Cited by 46 publications

(33 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, this may be a consequence of cancer registry indexing: in an Irish cohort with all skin cancers correctly registered, a 16-fold excess risk for BCC is present in KT patients compared to the age-matched general population [10]. The increased risk of tumors in KT subjects is one of the major topics in onconephrology [19].…”

Section: Introductionmentioning

confidence: 99%

Kidney Transplant Modifies the Architecture and Microenvironment of Basal Cell Carcinomas

Capasso

Viggiano

Lee

et al. 2020

Kidney Blood Press Res

Self Cite

View full text Add to dashboard Cite

Background/Aims: Basal cell carcinoma (BCC) is a frequent type of nonmelanoma skin cancer, which shows a greater prevalence in kidney-transplanted (KT) patients than in the general population. The study of this tumor in KT patients may allow us to understand the influence of the tumor inflammatory microenvironment on cancer behavior, and to design new image analysis methods to determine prognosis and apply personalized medicine. The major hypothesis of the present work is that antirejection drugs, by modifying the B-cell/T-cell balance, induce measurable differences in tumoral cell microarchitecture and in the inflammatory microenvironment in KT patients compared to nontransplanted controls. Methods: In this retrospective study in an Italian cohort including 15 KT patients and 15 control subjects from the general population who developed BCC, we analyzed tissue microarchitecture and inflammatory infiltrates of BCC using state-of-the-art nonlinear image analysis techniques such as fractal dimension and sample entropy of internuclear distances. Results: KT patients showed a nonsignificant trend to a greater number of nuclei in the basal cell layer compared to non-KT controls and subtle changes in the intact skin compared to controls. Similarly, the number of mitoses per unit length was almost doubled in the patients with KT compared to controls. However, when the number of mitotic cells was normalized by the total number of cells in the basal layer (mitotic index), these differences were not significant, although a clear trend was still present. Finally, KT patients showed a nonsignificant trend to an increased density of inflammatory cells close to the tumoral cell layer. When considering the intact skin, this difference was significant, with a 70% increase in the density of inflammatory cells. Conclusion: Data comparing the microarchitecture of BCC in normal subjects and KT patients are scanty, and the present study is the first to use nonlinear image analysis techniques to this aim. The observed differences underscore the relevance of T-cell suppression in cancer behavior. These data suggest that BCC develops in treated patients with specific biological characteristics which should be further analyzed in terms of therapeutic response.pipeline image analysis strategy to evaluate and assess the histology of basal cell layers in KT patients with BCC. Previous observations showed that BCC was clinically similar in the KT and the general population [12]: BCC occurrence was increased at the level of the head and neck region at an advanced age and the level of the trunk at a younger age. Furthermore, the literature on gender prevalence is somewhat inconsistent regarding BCC in KT, but in the general population males are more often affected than females (as in our sample). Finally, BCC is reported to have poor or scanty inflammatory response in the general popu-

show abstract

Section: Introductionmentioning

confidence: 99%

Kidney Transplant Modifies the Architecture and Microenvironment of Basal Cell Carcinomas

Capasso

Viggiano

Lee

et al. 2020

Kidney Blood Press Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several biomarkers like Cystatin C and further neutrophil gelatinase-associated lipocalin have consequently been recommended for the purpose of diagnosis, severity grouping and more essential, the modification in the AKI outcome [1]. Novel biomarkers are under investigation to determine whether they may enable earlier detection of decreased GFR and complications of AKI [3,111], as shown in Table 4.…”

Section: Biomarkers Of Acute Kidney Injury (Aki)mentioning

confidence: 99%

Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm

Thongprayoon

Hansrivijit

Kovvuru

et al. 2020

JCM

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a common clinical condition among patients admitted in the hospitals. The condition is associated with both increased short-term and long-term mortality. With the development of a standardized definition for AKI and the acknowledgment of the impact of AKI on patient outcomes, there has been increased recognition of AKI. Two advances from past decades, the usage of computer decision support and the discovery of AKI biomarkers, have the ability to advance the diagnostic method to and further management of AKI. The increasingly widespread use of electronic health records across hospitals has substantially increased the amount of data available to investigators and has shown promise in advancing AKI research. In addition, progress in the finding and validation of different forms of biomarkers of AKI within diversified clinical environments and has provided information and insight on testing, etiology and further prognosis of AKI, leading to future of precision and personalized approach to AKI management. In this this article, we discussed the changing paradigms in AKI: From mechanisms to diagnostics, risk factors, and management of AKI.

show abstract

“…Therefore, we have to consider it upon adjusting the drug dose using these estimates. 25 When taken together, based on the available evidence, the use of the CKD-EPI equation adjusted for BSA seems to be best option among the creatinine-based equations. In patients with cancer cachexia, the use of the cystatin C-based equation, or even more precisely isotopic GFR measurement, should be taken into consideration.…”

Section: The High Risk Of Overdosing and Underdosing Of Anticancer Drugsmentioning

confidence: 99%

“…However, the reader can easily imagine the usefulness of their implementation in oncological settings. 25 Going beyond the basal GFR: total number of nephrons and renal reserve GFR is the total amount of fluid filtered in all glomeruli in 2 kidneys. Therefore, any reduction in GFR may result from (i) a change in filtration at the level of each glomerulus, the average single nephron GFR, which is functional and could be, in certain instances, reversible; and (ii) the loss of nephrons (nephron index), which is irreversible because glomerulogenesis does not occur in adults.…”

Section: Assessment Of Renal Function In Akimentioning

confidence: 99%

How to assess kidney function in oncology patients

Małyszko

Lee

Capasso

et al. 2020

Kidney International

Self Cite

View full text Add to dashboard Cite

Summary of the International Conference on Onco-Nephrology: an emerging field in medicine

Cited by 46 publications

References 158 publications

Kidney Transplant Modifies the Architecture and Microenvironment of Basal Cell Carcinomas

Kidney Transplant Modifies the Architecture and Microenvironment of Basal Cell Carcinomas

Diagnostics, Risk Factors, Treatment and Outcomes of Acute Kidney Injury in a New Paradigm

How to assess kidney function in oncology patients

Contact Info

Product

Resources

About