Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion

Modesto, Adriana; Klein, Ophir D.; Tenuta, Livia Maria Andalo; Gerlach, Raquel Fernanda; Vieira, Alexandre R.

doi:10.5195/d3000.2013.16

Cited by 4 publications

(4 citation statements)

References 46 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Susceptibility to dental caries and DE has been suspected to involve a genetic component . Recent studies have reported positive associations between genetic variation in amelogenin, tuftelin, and enamelin and higher caries experience .…”

mentioning

confidence: 99%

Genetic variation may explain why females are less susceptible to dental erosion

Uhlen

Stenhagen

Dizak

et al. 2016

European J Oral Sciences

Self Cite

View full text Add to dashboard Cite

Not all individuals at risk for dental erosion (DE) display erosive lesions. The prevalence of DE is higher among male subjects. The occurrence of DE may depend on more than just acidic challenge, with genetics possibly playing a role. The aim of this study was to investigate the association of enamel-formation genes with DE. One premolar and a saliva sample were collected from 90 individuals. Prepared teeth were immersed in 0.01 M HCl (pH 2.2), and enamel loss (μm) was measured using white light interferometry. DNA was extracted from saliva, and 15 single-nucleotide polymorphisms were analysed. Allele and genotype frequencies were related to the enamel loss of the specimens. Single-marker and haplotype analyses were performed using sex as a covariate. Mean enamel loss was higher for male donors than for female donors (P = 0.047). Significant associations were found between enamel loss and amelogenin, X-linked (AMELX), tuftelin 1 (TUFT1), and tuftelin-interacting protein 11 (TFIP11). Analyses showed significant associations between variation in enamel-formation genes and a lower susceptibility to DE in female subjects. The results indicate that susceptibility to DE is influenced by genetic variation, and may, in part, explain why some individuals are more susceptible than others to DE, including differences between female subjects and male subjects.

show abstract

mentioning

confidence: 99%

Genetic variation may explain why females are less susceptible to dental erosion

Uhlen

Stenhagen

Dizak

et al. 2016

European J Oral Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Dental caries remains a major issue to be solved in oral healthcare medicine [9][10][11] . Owing to the dietary changes, dental caries caused by carbonated beverages has been reported frequently in the recent decades 12) .…”

Section: Introductionmentioning

confidence: 99%

Carbonated Soft Drink-Soaking Change the Crystallographic Properties of Human Tooth Enamel -A Micro-XRD Study

Kôno

Watanabe

Kanno

et al. 2019

J. Hard Tissue Biology.

View full text Add to dashboard Cite

To elucidate the crystallo-chemical reaction between the enamel and carbonated soft drink, a micro-X-ray diffraction analysis (micro-XRD) was conducted using the human tooth sections soaked in the drink (Sprite ®) for 1 and 7 days. In this study, 4 typically and heavily dissolved teeth were selected from 20 teeth, and the divergence of the crystallographic properties of the enamel was analyzed. All of the untreated human tooth enamels exhibited only the apatitic XRD patterns. We confirmed that the carbonated soft drink changed the macro-and microscopic morphological features of individual tooth enamel. The following 4 results were obtained from our study: i) the unit cell dimensions and crystallinity of the untreated enamel apatite varied between the layers and the individual teeth; ii) after the soaking experiment, the crystallographic properties of the enamels changed remarkably and displayed non-uniformity; iii) no relationship was discerned between the enamel's crystallographic properties and the sensitivity of the carious attack; and iv) the intermediate reaction product of soaking was uncovered; however, it was not identified at this time. The presence or absence of occurrence and variations in the amount of intermediate product reflected the complex chemical and crystallo-chemical reactions between the decalcification solution and the human tooth enamel crystallites. We clearly established that the untreated human tooth enamels differed in their crystallographic properties and did not react in the same manner, which resulted in varied apatitic structures after soaking. These results necessitate reconsideration of the generally accepted caries protection methods that are applied as common standards for all individuals and tooth enamels.

show abstract

“…These events take place in a time‐ and space‐restricted fashion in rat incisors, and distinct zones of secreting, maturing, and mature enamel are observed according to the developmental stages of those teeth . Enamel covers dental crown and its altered development increases susceptibility to caries . Therefore, it is pertinent to study the effects of systemic diseases such as T1DM on the formation of that structure.…”

Section: Introductionmentioning

confidence: 99%

Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis

Silva

Medeiros

Soares

et al. 2017

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Summary of the IADR Cariology Research, Craniofacial Biology, and Mineralized Tissue Groups Symposium, Iguaçu Falls, Brazil, June 2012: Gene-environment Interactions and Epigenetics in Oral Diseases: Enamel Formation and its Clinical Impact on Tooth Defects, Caries, and Erosion

Cited by 4 publications

References 46 publications

Genetic variation may explain why females are less susceptible to dental erosion

Genetic variation may explain why females are less susceptible to dental erosion

Carbonated Soft Drink-Soaking Change the Crystallographic Properties of Human Tooth Enamel -A Micro-XRD Study

Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis

Contact Info

Product

Resources

About