Summary of German‐Austrian HIV PrEP guideline

Abstract

Objectives HIV Pre‐Exposure prophylaxis (PrEP) is a strategy to reduce HIV transmission in people at risk. Aim of this first German‐Austrian PrEP guideline is to provide professional guidance on: when and in whom to use PrEP, recommended laboratory tests before and while on PrEP, selection of drugs, prevention of adverse events as a consequence of missing accompanying medical care, and general handling of PrEP in adults and adolescents. Methods Commented summary of of the S2k PrEP consensus guidelines released by the German and Austrian HIV medical societies to highlight the key recommendations of the guidelines. Content Detailed information about effectiveness of PrEP, when and in whom to use PrEP, as well as about additional monitoring of HIV PrEP are included in the HIV PrEP guidelines. Therewith detailed guidance for people being involved in PrEP counseling and associated care is provided.

Testing as Prevention of Resistance in Bacteria Causing Sexually Transmitted Infections—A Population-Based Model for Germany

“…While inappropriate antimicrobial therapy (e.g., due to suboptimal choice of antimicrobial drugs or due to subtherapeutic and thus resistance-selecting dosage) is usually not intended, it may easily occur if the respective infection is unknown due to a subclinical course, a problem which has been extensively discussed during the roll-out of HIV (human immunodeficiency virus) PrEP [ 30 ]. As, for example, stated in the German-Austrian HIV-PrEP guideline [ 31 ], it makes sense to exclude prevalent infection prior to prophylactic use of antimicrobial drug application in order to prevent selection of antimicrobial resistance. Other than antibiotic drugs, however, anti-retroviral drugs are usually not applied, apart from HIV-specific therapy, HIV-PEP, and HIV-PrEP, so the risk of resistance selection by chance is quite low.…”

Seroconversion rate of SARS-CoV-2 IgG antibodies and dating behaviour in HIV-PrEP users in a German metropolis during the COVID-19 pandemic

“…Syphilis serology was performed at every visit according to the German national PrEP guidelines. 5 PCRs for typical STI pathogens (NG, CT, MG) were performed according to standard protocols, if STI symptoms were present. Data on history and/or symptoms of COVID-19, as well as of STIs, personal risk behavior and number of sexual contacts were recorded at every visit using the same digital questionnaire at each visit.…”

“…A rising number of MSM use PrEP consisting of two antiviral substances (emtricitabine/tenofovir disoproxil fumarate, FTC/TDF) for the prevention of an HIV-infection. 5 This medication can be taken continuously or on demand for scheduled dates as off-label use. Since PrEP offers no protection against other sexually transmitted infections (STIs), PrEP users receive routine check-ups for infections with hepatitis C, Treponema pallidum (TP) and Neisseria gonorrhoae (NG), Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) every 3 months.…”

57-jährige Patientin mit ungewöhnlicher Häufung infektiöser Hauterkrankungen

“…durchzuführen [3]. Eine zeitnahe Therapieeinleitung bei Infizierten ist notwendig und hilft neben anderen Maßnahmen wie Safer Sex und medikamentöser Präexpositionsprophylaxe Neuinfektionen einzudämmen [4]. Bei Aufnahme der Patientin bestand eine sehr hohe Viruslast und somit ein Übertragungsrisiko für Sexualpartner und medizinisches Personal.…”