Sumatriptan therapy for headache and acute myocardial infarction

Barra, Silvia; Lanero, Simona; Madrid, Alfredo; Materazzi, Crescenzo; Vitagliano, Giancarlo; Ames, P. R. J.; Gaeta, Giovanni Battista

doi:10.1517/14656566.2010.522567

Cited by 22 publications

(14 citation statements)

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“…Several of the migraine abortive therapies, particularly triptans and ergot alkaloids, have vasoconstrictive effects that may predispose individuals to ischemic events. [31] However, large population studies have not found an increased risk of adverse vascular events among migraineurs using triptan therapy. [3233] Medication overuse, however, may be more problematic.…”

Section: Why Are Migraine and Stroke Comorbid Conditions?mentioning

confidence: 99%

Migraine, cerebrovascular disease and the metabolic syndrome

Sinclair

Matharu

2012

Ann Indian Acad Neurol

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Evidence is emerging that migraine is not solely a headache disorder. Observations that ischemic stroke could occur in the setting of a migraine attack, and that migraine headaches could be precipitated by cerebral ischemia, initially highlighted a possibly association between migraine and cerebrovascular disease. More recently, large population-based studies that have demonstrated that migraineurs are at increased risk of stroke outside the setting of a migraine attack have prompted the concept that migraine and cerebrovascular disease are comorbid conditions. Explanations for this association are numerous and widely debated, particularly as the comorbid association does not appear to be confined to the cerebral circulation as cardiovascular and peripheral vascular disease also appear to be comorbid with migraine. A growing body of evidence has also suggested that migraineurs are more likely to be obese, hypertensive, hyperlipidemic and have impaired insulin sensitivity, all features of the metabolic syndrome. The comorbid association between migraine and cerebrovascular disease may consequently be explained by migraineurs having the metabolic syndrome and consequently being at increased risk of cerebrovascular disease. This review will summarise the salient evidence suggesting a comorbid association between migraine, cerebrovascular disease and the metabolic syndrome.

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Section: Why Are Migraine and Stroke Comorbid Conditions?mentioning

confidence: 99%

Migraine, cerebrovascular disease and the metabolic syndrome

Sinclair

Matharu

2012

Ann Indian Acad Neurol

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“…This class of medications inhibits the release of vasoactive peptides and promotes vasoconstriction, combating the pathologic vasodilatation contributing to migraine headaches. 1 Potential complications of these vasoconstrictive properties include myocardial infarction, 2 , 3 cerebrovascular accident, 4 ischemic colitis, 5 and spinal cord infarction. 6 We present a case of bilateral renal infarctions associated with sumatriptan use.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Renal Infarctions During the Use of Sumatriptan

Abramovitz

Leonberg‐Yoo

Bahrainwala

et al. 2018

Kidney International Reports

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“…3 The arterial vasoconstriction is enhanced when endothelial function is impaired as it is, for example, in smokers. 3 The arterial vasoconstriction is enhanced when endothelial function is impaired as it is, for example, in smokers.…”

Section: Expert Commentarymentioning

confidence: 99%