Sumatriptan Iontophoretic Patch for Migraine

Tepper, David

doi:10.1111/head.12453

Cited by 2 publications

(1 citation statement)

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“…Iontophoretic drug delivery is generally considered safe and noninvasive such as in transdermal and ocular iontophoresis. For example, the US Food and Drug Administration (FDA) has approved iontophoresis treatments such as transdermal fentanyl (Ionsys in 2015, Medicines Co., Parsippany, NJ, USA) [ 35 , 36 ] and sumatriptan (Zecuity in 2013, NuPathe/Teva) [ 37 , 38 ], topical pilocarpine for sweat stimulation (e.g., Nanoduct and Macroduct) [ 39 , 40 ], topical lidocaine for local skin anesthesia (e.g., Iontocaine and Lidosite) [ 41 , 42 ], and transtympanic lidocaine for tympanic membrane anesthesia [ 43 , 44 ]. Reverse transdermal iontophoresis for glucose monitoring was also approved [ 45 ].…”

Section: Iontophoretic Drug Deliverymentioning

confidence: 99%

Iontophoretic Drug Delivery in the Oral Cavity

Wanasathop

2018

Pharmaceutics

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Iontophoresis is a noninvasive method to enhance systemic and local drug delivery by the application of an electric field. For systemic drug delivery in the oral cavity, iontophoresis was studied primarily for transbuccal delivery. Significant enhancement of drug delivery was observed in buccal iontophoresis compared to passive transport for different drugs. For local drug delivery in the oral cavity, iontophoresis could enhance drug penetration into the enamel, dentin, and other oral tissues for the treatment of oral diseases. Iontophoresis was evaluated in dentistry such as to produce local anesthesia and treat tooth decalcification and hypersensitivity, but this technology has not been fully utilized. The most common drugs in these evaluations were fluoride and lidocaine. In general, there is limited knowledge of the mechanisms of iontophoresis in the oral tissues. In vivo animal and human studies have suggested that iontophoresis is safe in the oral cavity under the conditions investigated. The present review covers the topics of iontophoretic drug delivery in the oral cavity for both systemic and local treatments. The anatomy and diseases in the oral cavity for iontophoretic drug delivery are also briefly reviewed, and the challenges for this drug delivery method are discussed.

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