Sumario ejecutivo de las recomendaciones SEPAR de diagnóstico y tratamiento del cáncer de pulmón de células no pequeñas

Abstract

The Thoracic Surgery and Thoracic Oncology groups of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) have backed the publication of a handbook on recommendations for the diagnosis and treatment of non-small cell lung cancer. Due to the high incidence and mortality of this disease, the best scientific evidence must be constantly updated and made available for consultation by healthcare professionals. To draw up these recommendations, we called on a wide-ranging group of experts from the different specialties, who have prepared a comprehensive review, divided into 4 main sections. The first addresses disease prevention and screening, including risk factors, the role of smoking cessation, and screening programs for early diagnosis. The second section analyzes clinical presentation, imaging studies, and surgical risk, including cardiological risk and the evaluation of respiratory function. The third section addresses cytohistological confirmation and staging studies, and scrutinizes the TNM and histological classifications, non-invasive and minimally invasive sampling methods, and surgical techniques for diagnosis and staging. The fourth and final section looks at different therapeutic aspects, such as the role of surgery, chemotherapy, radiation therapy, a multidisciplinary approach according to disease stage, and other specifically targeted treatments, concluding with recommendations on the follow-up of lung cancer patients and surgical and endoscopic palliative interventions in advanced stages.

Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats

“…Muscle mass loss and wasting are characteristic features of patients with chronic conditions such as chronic heart failure, diabetes, renal failure, chronic obstructive pulmonary disease (COPD), cancer, and critical illness ( Alvarez et al, 2016 ; Barreiro et al, 2015 ; Barreiro, 2017 ; Diaz, Ospina-Tascon & Salazar, 2014 ; Evans et al, 2008 ; Fearon et al, 2011 ; Villar et al, 2016 ; Von & Anker, 2010 ) Cachexia is characterized by severe body weight and muscle loss together with alterations in metabolic parameters. Patients with cachexia experience severe muscle weakness, which has been consistently demonstrated to predict morbidity and mortality ( Barreiro et al, 2015 ; Evans et al, 2008 ; Fearon et al, 2011 ; Mador, Bozkanat & Kufel, 2003 ; Marquis et al, 2002 ; Patel et al, 2014 ; Seymour et al, 2010 ; Swallow et al, 2007 ).…”

Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis

“…It has also been commonly used as a nutraceutical in both human and animal models [20]. In several species, resveratrol also increased lifespan, probably through prevention of processes such as redox imbalance, inflammation, obesity, diabetes, and atherosclerosis [21][22][23][24]. In skeletal muscles, resveratrol was shown to reduce injury of gastrocnemius in rats [25].…”