In a preceding study in the heavy quark limit of QCD, it has been demonstrated that the best lower bound on the curvature of the Isgur-Wise function16 . The quadratic term (ρ 2 ) 2 is dominant in a non-relativistic expansion in the light quark, both ξ ′′ (1) and (ρ 2 ) 2 scaling like (R 2 m 2 q ) 2 , where m q is the light quark mass and R the bound state radius. The non-relativistic limit is thus a good guide-line in the study of the shape of ξ(w). In the present paper we obtain similar bounds on all the derivatives of ξ N R (w), the IW function with the light quark non-relativistic, and we demonstrate that these bounds are optimal. Our general method is based on the positivity of matrices of moments of the ground state wave function, that allows to bound the n-th derivative ξ (n) N R (w) in terms of the m-th ones (m < n). We show that the method can be generalized to the true Isgur Wise function of QCD ξ(w).