Sum Frequency Generation Spectroscopy in Biosensors Technology

Volcke, Cédric; Caudano, Yves; Péremans, A.

doi:10.5772/17209

Cited by 2 publications

(2 citation statements)

References 101 publications

(117 reference statements)

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“…Unfortunately, this is not the case for squalene, which can adopt almost 125 000 distinct conformers, based on the conformational flexibility of the main carbon chain dihedral angles alone (see Section and Supporting Information Section SI.3 for a full discussion). For even larger molecules such as lipids, peptides, and proteins, although there have been reports of peak assignments in the C–H stretching region, they are based on spectral fitting and previous common assignments of alkyl chains or amino acids. − For proteins, motifs such as amide bonds that provide more information on the secondary structures are gaining more research interest. ,− …”

Section: Introductionmentioning

confidence: 99%

Molecular Orientation at the Squalene/Air Interface from Sum Frequency Generation Spectroscopy and Atomistic Modeling

et al. 2021

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Human skin oils are significant scavengers of atmospheric oxidants in occupied indoor environments, and squalene is a major ozone-active constituent. Here, we present a combined spectroscopic and atomistic modeling approach to elucidate the conformational and orientational preferences of squalene at the air/oil interface and their implications for reactions with ozone. We find that squalene chains have a tendency to align with the surface normal, resulting in different concentrations of the various types of its double bonds and thus different reactivities. We also observe the presence of water at the surface of this hydrophobic compound. Both findings have possible implications for the design and outcomes of kinetic models describing this important aspect of indoor air chemistry.

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Section: Introductionmentioning

confidence: 99%

Molecular Orientation at the Squalene/Air Interface from Sum Frequency Generation Spectroscopy and Atomistic Modeling

et al. 2021

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“…Mathematically, w is a tensor with a 3 n+1 component. 174 The higher order w terms are extremely small compared to w (1) when a material is irradiated with typical IR or Raman irradiation sources. However, these terms become significant when the material is irradiated with high-intensity laser beams.…”

Section: Sum-frequency Generation Vibrational Spectroscopy (Sfg)mentioning

confidence: 99%