Sulpiride effects on nigral and striatal glutamic acid decarboxylase activity: A possible involvement of prolactin

Nicoletti, Ferdinando; Canonico, Pier Luigi; Patti, Francesco; Rampello, Liborio; Condorelli, D. F.; Giammona, G.; Giorgio, Rosa María Di; Scapagnini, U.

doi:10.1016/0014-2999(82)90007-3

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…It is consistent with this hypothesis that an increase in nigral and striatal GAD activity is observed in conditions of hyperpro lactinemia induced by surgical or pharmacological proce dures [14]; moreover, in ovariectomised rats, hyperprolacti nemia resulting from anterior pituitary transplantation un der the kidney capsule has been found to be associated with changes in MBH GABA concentration without any signifi cant modification in GABA turnover [II], These observa-…”

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confidence: 72%

Effects of Hyper- and Hypoprolactinemia on Glutamate Decarboxylase Activity in Medial Basal Hypothalamus of Male Rat

et al. 1983

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Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

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confidence: 72%

Effects of Hyper- and Hypoprolactinemia on Glutamate Decarboxylase Activity in Medial Basal Hypothalamus of Male Rat

et al. 1983

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“…Nevertheless, numerous other studies in which our own findings with regard to the absence of localization of Sulpiride in the brain of rodents were taken into account, suggest a different and indirect mode of action (16,17,18,19,20,21). Furthermore, Sulpiride, as has been clearly demonstrated in numerous studies is very potent in stimulating prolactin secretion in laboratory animals and in man (22,23,24,25).…”

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confidence: 94%

Autoradiographic study of14C-Sulpiride in monkey

Benakis

Brown

Bénard

1984

European Journal of Drug Metabolism and Pharmacokinetics

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Substituted benzamides have been the object of numerous metabolic studies including many by whole body autoradiography of rats and mice. The present study reports autoradiographic data concerning 14C-labelled Sulpiride in monkey. The Study was limited to the brain in order to elucidate the controversial question as to whether the drug can cross the blood-brain barrier. The results showed that in monkey, as in rat and mouse, there is no localization in the brain as can be clearly seen on the autoradiograms. In view of these results and of the undeniable neuroleptic properties of Sulpiride, an indirect mode of action through the release of endogenous mediators is proposed.

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Psychotropic properties of ovarian estrogens (review)

Arushanyan

Borovkova

1989

Neurosci Behav Physiol

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Sulpiride effects on nigral and striatal glutamic acid decarboxylase activity: A possible involvement of prolactin

Cited by 7 publications

References 20 publications

Effects of Hyper- and Hypoprolactinemia on Glutamate Decarboxylase Activity in Medial Basal Hypothalamus of Male Rat

Effects of Hyper- and Hypoprolactinemia on Glutamate Decarboxylase Activity in Medial Basal Hypothalamus of Male Rat

Autoradiographic study of14C-Sulpiride in monkey

Psychotropic properties of ovarian estrogens (review)

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