Sulphonamides: updates on use in veterinary medicine

Campbell, Karen

doi:10.1046/j.1365-3164.1999.00181.x

Cited by 22 publications

(11 citation statements)

References 20 publications

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“…In our study, the highest SCP levels were also obtained from liver samples. The study results reveal that, the accumulation of SCP in liver was high like other studies [4] .…”

Section: Discussionsupporting

confidence: 66%

“…It is used for the treatment of coli-bacteriosis, cholera and coccidiosis in drinking water for 3-6 days, at the dose of 30-50 mg/kg. If it is necessary, daily dose can be given up to 400 mg/kg [1][2][3][4] . SCP is also used in aquaculture and as a feed additive especially for pigs and cattle [5,6] .…”

Section: Effects Of Various Cooking and Freezing Processes On Thementioning

confidence: 99%

“…Concentrations of TMP are higher in tissues than serum. TMP is metabolized by the liver to oxide and hydroxylated metabolites [4] . After the sulfonamide administration of animals, sulfonamide residues can be found in meat for a long time and they migh cause allergic reactions for human and animals.…”

Section: Effects Of Various Cooking and Freezing Processes On Thementioning

confidence: 99%

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Effects of Various Cooking and Freezing Processes on the Residues of Sulfachlorpyridazine-Trimethoprim Combination in Broiler Tissues

Kanbur¹,

Liman²,

Eraslan³

et al. 2014

Kafkas Univ Vet Fak Derg

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SummaryThis study was conducted to determine the effects frying, boiling and freezing processes on the levels of sulfachlorpyridazine (SCP) and trimethoprim (TMP) in broiler chest meat and liver. Male broiler chicks were assigned to two groups as control and treatment groups. Animals were fed on commercial diet not containing SCP and TMP for 35 days. At 30 th day, experimental group received suspensions of SCP-TMP mixture (30 mg/kg SCP and 6 mg/kg TMP) via craw by gavage once daily for 5 days. At the end of 35 th day, the chickens were sacrified and right chest tissue and the liver were taken out. A portion of the tissues were stored in -20°C freezer for 30 and 45 days. After sacrifiying, the raw tissues were exposed to frying and boiling processes. SCP and TMP analysis of tissues were performed by HPLC-DAD detector and reverse phase column. In conclusion, it has been determined that boiled and grilled processes caused a reduction of SCP and TMP residues at different rates in broiler tissues; while storing in the deep freezer did not cause a significant change on SCP and TMP residues.Keywords: Sulfachlorpyridazine, Trimethoprim, Broiler meat, Liver, Cooking, Freezing, HPLC Sülfaklorpridazin-Trimetoprim Karışımının Broyler Dokularındaki Kalıntıları Üzerine Çeşitli Pişirme ve Dondurma İşlemlerinin Etkileri ÖzetBu araştırmayla kızartma, haşlama ve dondurma işlemlerinin piliç göğüs eti ve karaciğer dokularındaki sülfaklorpridazin (SCP) ve trimetoprim (TMP) kalıntılarına yönelik etkilerinin ortaya konulması amaçlandı. Erkek broyler civcivlerden kontrol ve deneme olmak üzere 2 çalışma grubu oluşturuldu. Hayvanlar 35 gün boyunca SCP ve TMP içermeyen yemle beslendi. Deneme grubundaki civcivlere otuzuncu günden itibaren SCP-TMP karışımı (30 mg/kg SCP, 6 mg/kg TMP) 5 gün boyunca günde 1 kez sonda ile kursağa verildi. 35. günün sonunda hayvanlar kesilerek sağ göğüs dokusu ve karaciğerleri alındı. Dokuların bir kısmı 30 ve 45 gün boyunca -20°C'lik derin dondurucuda saklandı. Kesim sonrası alınan çiğ dokulara kızartma ve haşlama işlemleri uygulandı. Dokuların SCP ve TMP analizleri DAD dedektör ve ters faz kolon ile HPLC'de gerçekleştirildi. Sonuç olarak, haşlama ve ızgara işlemlerinin broyler dokularında SCP ve TMP kalıntılarında değişik oranlarda azalmaya neden olduğu; derin dondurucuda bekletmenin ise SCP ve TMP kalıntıları üzerinde önemli bir değişime yol açmadığı belirlendi.

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“…In our study, the highest SCP levels were also obtained from liver samples. The study results reveal that, the accumulation of SCP in liver was high like other studies [4] .…”

Section: Discussionsupporting

confidence: 66%

Section: Effects Of Various Cooking and Freezing Processes On Thementioning

confidence: 99%

Section: Effects Of Various Cooking and Freezing Processes On Thementioning

confidence: 99%

See 1 more Smart Citation

Effects of Various Cooking and Freezing Processes on the Residues of Sulfachlorpyridazine-Trimethoprim Combination in Broiler Tissues

Kanbur¹,

Liman²,

Eraslan³

et al. 2014

Kafkas Univ Vet Fak Derg

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“…3 The reported adverse effects of potentiated sulfonamides are numerous, varied, and id- iosyncratic and dose dependent in nature. Two formulations are available: the proprietary compound (TMS a ) and a generic form (T-SMX).…”

Section: Discussionmentioning

confidence: 99%

Goitrous hypothyroidism associated with treatment with trimethoprim-sulfamethoxazole in a young dog

Seelig¹,

Whittemore²,

Lappin³

et al. 2008

javma

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To the authors' knowledge, this is the first report of antimicrobial-induced goiter in a dog. Cytologic examination of fine-needle aspirates and interpretation of data from serum biochemical and thyroid function analyses were needed to obtain a definitive diagnosis. Practitioners should include goiter among the differential diagnoses for ventral neck swellings in young dogs receiving potentiated sulfonamide antimicrobials.

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“…However, a susceptibility test should always be used to confirm whether or not these drugs may have activity against isolates from animals. The use of these medications in veterinary dermatology has been discussed previously 16–18 . Most staphylococci are also susceptible to nitrofurantoin, but this drug is used only for urinary tract infections and will not be discussed here.…”

Section: Antibiotic Choices For Meticillin‐resistant Staphylococcusmentioning

confidence: 99%

Selection of antibiotics for meticillin‐resistantStaphylococcus pseudintermedius: time to revisit some old drugs?

Papich

2012

Veterinary Dermatology

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The aim of this review is to consider systemic therapy options for meticillin-resistant Staphylococcus pseudintermedius (MRSP). Infections caused by MRSP in small animals--particularly dogs--have been frustrating veterinarians in recent years. After a susceptibility test is performed, veterinarians are left to select from drugs that have not been frequently encountered on a susceptibility report. Some of these are old drugs that have not been used regularly by veterinary dermatologists. As MRSP is, by definition, resistant to all β-lactam antibiotics, including cephalosporins, penicillins and amoxicillin-clavulanate combinations, the β-lactam drugs are not an option for systemic treatment. As most MRSPs are multidrug resistant, familiar drugs, such as trimethoprim-sulfonamides, fluoroquinolones, macrolides and lincosamides (clindamycin), are also not usually an option for treatment. Therefore, veterinarians are left with drugs such as rifampicin, chloramphenicol, tetracyclines, aminoglycosides and vancomycin to choose from on the basis of an in vitro susceptibility test. Some of these drugs were originally approved over 50 years ago and may not be familiar to some veterinarians. Each of these drugs possesses unique properties and has particular advantages and disadvantages. Veterinarians should be particularly aware of the adverse effects, limitations and precautions when using these drugs. New drugs also have been developed for meticillin-resistant Staphylococcus aureus in humans. These include linezolid, ceftaroline, daptomycin and tigecycline. Although these drugs are very infrequently--if ever--considered for veterinary use, the properties of these drugs should also be known to veterinary dermatologists.

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Sulphonamides: updates on use in veterinary medicine

Cited by 22 publications

References 20 publications

Effects of Various Cooking and Freezing Processes on the Residues of Sulfachlorpyridazine-Trimethoprim Combination in Broiler Tissues

Effects of Various Cooking and Freezing Processes on the Residues of Sulfachlorpyridazine-Trimethoprim Combination in Broiler Tissues

Goitrous hypothyroidism associated with treatment with trimethoprim-sulfamethoxazole in a young dog

Selection of antibiotics for meticillin‐resistantStaphylococcus pseudintermedius: time to revisit some old drugs?

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