Sulphomucins favour adhesion of Helicobacter pylori to metaplastic gastric mucosa.

Bravo, Juan Carlos; Correa, Pelayo

doi:10.1136/jcp.52.2.137

Cited by 19 publications

(18 citation statements)

References 13 publications

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“…In the evaluation of the infection status, it is worthwhile to note that H. pylori colonization is typically absent in the IM foci of the complete type, whereas it may be present in the adjacent nonmetaplastic gastric mucosa and in IM of the incomplete type (58). In addition, decreased sensitivity of the rapid urease test is observed in subjects taking proton pump inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Pathology of Gastric Intestinal Metaplasia: Clinical Implications

Correa

Piazuelo²,

Wilson³

2010

American Journal of Gastroenterology

327

277

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Section: Discussionmentioning

confidence: 99%

Pathology of Gastric Intestinal Metaplasia: Clinical Implications

Correa

Piazuelo²,

Wilson³

2010

American Journal of Gastroenterology

327

277

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“…Among adults 140 years of age, H. pylori infection may become less prevalent with advanced age [30]. This decrease is thought to directly result from H. pylori-induced damage to gastric epithelium; chronic H. pylori infection leads both to intestinal metaplasia of gastric cells (to which H. pylori adhere less readily) [31,32] and to gastric atrophy and hypochlorhydria (allowing competition from other microorganisms).…”

Section: Epidemiologymentioning

confidence: 99%

Helicobacter pylori:Consensus and Controversy

Passaro¹,

Chosy

Parsonnet

2002

CLIN INFECT DIS

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Helicobacter pylori is uniquely adapted to colonize the human stomach. Infection leads to a range of subclinical and clinical outcomes that depend on properties of the infecting strain, the host, and the environment. Eradication therapy is indicated for infected persons who develop peptic ulcer disease or gastric lymphoma or who are beginning long-term treatment with nonsteroidal anti-inflammatory drugs. However, treatment may worsen gastroesophageal reflux disease and increase the risk of esophageal cancer. H. pylori infections can be diagnosed noninvasively and can be eradicated with approximately 85% success by a variety of multidrug, 7-14-day regimens. Unfortunately, antibiotic resistance is affecting treatment effectiveness in the United States and abroad. A more complete understanding of the variation in H. pylori pathogenesis should lead to clearer recommendations about treatment for infected persons who have neither peptic ulcer disease nor gastric lymphoma.

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“…Interestingly, there appears to be a correlation between the type of glycoconjugate to which microbes preferentially bind and the glycoconjugate-cleavage machinery of the respective microorganisms (Hoyer et al, 1992;Slomiany et al, 1992;Bravo and Correa, 1999;Vimal et al, 2000). Furthermore, it has been suggested that adhesion to mucin can trigger the production of various mucolytic strategies to overcome mucus entrapment.…”

Section: Host-microbe Interactions At Mucosal Interfaces In Metazoansmentioning

confidence: 99%