Sulphane sulphur in biological systems: a possible regulatory role

Toohey, John I.

doi:10.1042/bj2640625

Cited by 227 publications

(189 citation statements)

References 138 publications

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“…Following release, hydrogen sulfide can be stored in cells as bound sulfane sulfur that can be released by reducing conditions (44). Bound sulfane sulfur is the major determinant of physiological functions of hydrogen sulfide (45)(46)(47). Recent studies indicate that hydrogen sulfide has diverse effects on cell function including cell survival, hemodynamics, and inflammation (44); however, its role in protein synthesis has not been examined in detail.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells

Lee

Mariappan

Féliers

et al. 2012

Journal of Biological Chemistry

112

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Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells

Lee

Mariappan

Féliers

et al. 2012

Journal of Biological Chemistry

112

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“…These are briefly described in the next few paragraphs; detailed reviews can be found in Refs. (75,86,134,135,167,168,181,196). The downstream consequences of these initial signaling events on ion channel permeability, transport processes, enzyme activity, or structural proteins are not considered.…”

Section: Mechanism Of H 2 S Signalingmentioning

confidence: 99%

Hydrogen sulfide as an oxygen sensor

Olson

2013

Clinical Chemistry and Laboratory Medicine

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Significance: Although oxygen (O 2 )-sensing cells and tissues have been known for decades, the identity of the O 2 -sensing mechanism has remained elusive. Evidence is accumulating that O 2 -dependent metabolism of hydrogen sulfide (H 2 S) is this enigmatic O 2 sensor. Recent Advances: The elucidation of biochemical pathways involved in H 2 S synthesis and metabolism have shown that reciprocal H 2 S/O 2 interactions have been inexorably linked throughout eukaryotic evolution; there are multiple foci by which O 2 controls H 2 S inactivation, and the effects of H 2 S on downstream signaling events are consistent with those activated by hypoxia. H 2 S-mediated O 2 sensing has been demonstrated in a variety of O 2 -sensing tissues in vertebrate cardiovascular and respiratory systems, including smooth muscle in systemic and respiratory blood vessels and airways, carotid body, adrenal medulla, and other peripheral as well as central chemoreceptors. Critical Issues: Information is now needed on the intracellular location and stoichometry of these signaling processes and how and which downstream effectors are activated by H 2 S and its metabolites. Future Directions: Development of specific inhibitors of H 2 S metabolism and effector activation as well as cellular organelle-targeted compounds that release H 2 S in a timeor environmentally controlled way will not only enhance our understanding of this signaling process but also provide direction for future therapeutic applications. Antioxid. Redox Signal. 22, 377-397.

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“…Toohey suggested that the malignant proliferation of cells may be related to a deficiency of sulfane sulfur. In fact, the observed defective sulfur metabolism in cancer cells and the anti-cancer effects in vivo of sulfane sulfur compounds may be due to the uncontrolled activity of a set of enzymes normally inactivated by sulfane sulfur (Toohey 1989). Cutting and crushing of garlic cloves induces the release of the vacuolar enzyme alliinase (alliin lyase EC.…”

Section: Introductionmentioning

confidence: 99%

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

2010

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Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis. The biochemical mechanisms underlying the antitumorigenic and anti-proliferative effects of garlic-derived OSCs are not fully understood. Several modes of action of these compounds have been proposed, and it seems likely that the rate of clearance of allyl sulfur groups from cells is a determinant of the overall response. The aim of this review is to focus attention on the effects of natural allyl sulfur compounds on the cell detoxification system in normal and tumor cells. It has been already reported that several natural allyl sulfur compounds induce chemopreventive effects by affecting xenobiotic metabolizing enzymes and inducing their down-activation. Moreover, different effects of water-and oil-soluble allyl sulfur compounds on enzymes involved in the detoxification system of rat tissues have been observed. A direct interaction of the garlic allyl sulfur compounds with proteins involved in the detoxification system was studied in order to support the hypothesis that proteins possessing reactive thiol groups and that are involved in the detoxification system and in the cellular redox homeostasis, are likely the preferential targets of these compounds. The biochemical transformation of the OSCs in the cell and their adducts with thiol functional groups of these proteins, could be considered relevant events to uncover the anticancer properties of the allyl sulfur compounds. Although additional studies, using proteomic approaches and transgenic models, are needed to identify the molecular targets and modes of action of these natural compounds, the allyl sulfur compounds can represent potential ideal agents in anticancer therapy, either alone or in association with other antitumor drugs.

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Sulphane sulphur in biological systems: a possible regulatory role

Cited by 227 publications

References 138 publications

Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells

Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells

Hydrogen sulfide as an oxygen sensor

Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy

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