Sulindac increases the expression of APC mRNA in malignant colonic epithelial cells: an in vitro study.

Schnitzler, Margaret; Dwight, Trisha; Robinson, Bruce G.

doi:10.1136/gut.38.5.707

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…control cell to cell adhesion and cell rmigration (Nathke et al 1996: Barth et al 1997 (Schnitzler et al 1996). and it has been suggested that this effect might explain, at least in part.…”

Section: Discussionmentioning

confidence: 99%

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours

Giarola

Wells²,

Mondini³

et al. 1998

Br J Cancer

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“…control cell to cell adhesion and cell rmigration (Nathke et al 1996: Barth et al 1997 (Schnitzler et al 1996). and it has been suggested that this effect might explain, at least in part.…”

Section: Discussionmentioning

confidence: 99%

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours

Giarola

Wells²,

Mondini³

et al. 1998

Br J Cancer

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“…Sulindac sulfide induces a dose-dependent inhibition of cell proliferation on epithelial cell lines derived from colorectal cancer [35]. Sulindac sulfone reduces the growth of colon cancer precursors in rats [36].…”

Section: Discussionmentioning

confidence: 99%

Long-term treatment with sulindac in familial adenomatous polyposis: Is there an actual efficacy in prevention of rectal cancer?

et al. 2000

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“…One possible mechanism is that sulindac increases expression of APC (Schnitzler et al, 1996;Kishimoto et al, 2000) and that APC decreases survivin expression because, as we have shown (Zhang et al, 2001), APC downregulates survivin through the ␤-catenin:Tcf-4 pathway. However, HT-29 cells lack wild-type APC, which excludes this possibility.…”

Section: Discussionmentioning

confidence: 99%

The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma Cells

Zhang

Fields²,

Ehrlich³

et al. 2003

J Pharmacol Exp Ther

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Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac have chemopreventive activity against colorectal tumors. Although the molecular mechanism has not been fully established, it is thought to involve the ability of NSAIDs to induce apoptosis. Because the majority of colon carcinomas are known to overexpress antiapoptotic proteins such as survivin and Bcl-2 and show only limited ability to undergo apoptosis, we hypothesized that the ability of sulindac to cause regression of adenomas and to inhibit colon carcinogenesis is mediated, at least in part, by down-regulation of one or more of these antiapoptotic proteins. To test this hypothesis, we exposed HT-29 colon carcinoma cells to sulindac. Sulindac induced a sustained decrease in mRNA and protein expression for survivin but not for Bcl-2. This finding suggests that sulindac is selectively acting through a survivin-related pathway. This is consistent with our earlier finding that inhibition of the ␤-catenin:T-cell factor 4 (Tcf-4) pathway by the adenomatous polyposis coli protein down-regulates survivin expression and with recent evidence that sulindac induces ␤-catenin degradation, which would reduce Tcf-4 activation. This suggests that the ␤-catenin:Tcf-4:survivin mechanism may be a useful target for therapy or chemoprevention of colon cancer.

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Sulindac increases the expression of APC mRNA in malignant colonic epithelial cells: an in vitro study.

Abstract: Background-Sulindac is a non-steroidal anti-inflammatory drug which induces regression of colonic polyps in patients with familial adenomatous polyposis. Animal and in vitro studies have shown that both the sulphide metabolite of sulindac, which is able to inhibit cyclo-oxy-

Cited by 19 publications

References 34 publications

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours

Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours

Long-term treatment with sulindac in familial adenomatous polyposis: Is there an actual efficacy in prevention of rectal cancer?

The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma Cells

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