Sulfur inhibits the growth of androgen-independent prostate cancer in vivo

Duan, Fei; Li, Yuhua; Chen, Liangkang; Zhou, Xiaoyu; Chen, Jianxing; Chen, Hailin; R, Li

doi:10.3892/ol.2014.2700

Cited by 17 publications

(14 citation statements)

References 23 publications

(28 reference statements)

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“…Several studies suggest that H 2 S may regulate cancer cell growth and tumor progression and that the expression of CSE and CBS is reduced in antiandrogen-resistant prostate cancer cells. Additionally, in antiandrogen-resistant prostate cancer cells, lower levels of endogenous H 2 S were found [250,251]. Interestingly, Enzalutamide [252,253] and Apalutamide [254], the androgen receptor antagonists that are used in the prostate cancer treatment, are N, N-disubstituted thiourea derivatives ( Figure 19).…”

Section: Other Drugsmentioning

confidence: 99%

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

et al. 2020

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Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early clinical studies. For example, H2S donors have been found to be effective in the prevention of gastrointestinal ulcers during anti-inflammatory treatment. Notably, there are well-established medicines used for the treatment of a variety of diseases, whose chemical structure contains sulfur moieties and may release H2S. Hence, the therapeutic effect of these drugs may be partly the result of the release of H2S occurring during drug metabolism and/or the effect of these drugs on the production of endogenous hydrogen sulfide. In this work, we review data regarding sulfur drugs commonly used in clinical practice that can support the hypothesis about H2S-dependent pharmacotherapeutic effects of these drugs.

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Section: Other Drugsmentioning

confidence: 99%

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

et al. 2020

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“…In that research, prostate tumors were developed by injecting 22 Rv1 or DU 145 PCa cells into sulfur treated and untreated nude mice. The results showed that sulfur inhibited the growth of androgen independent prostate cancer in vivo [ 13 ]. Furthermore, the intake of refined inorganic sulfur has been reported to reduce the clinical side effects of radiotherapy in cancer patients [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats

2015

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Objectives:This study was performed to analyze the single-dose oral toxicity of the super key (processed sulfur).Methods:All experiments were conducted at Medvill, an institution authorized to perform non-clinical studies, under the Good Laboratory Practice (GLP) regulations. In order to investigate the oral toxicity of super keyWe administered it orally to Sprague-Dawley (SD) rats. The SD rats were divided into four groups of five male and five female animals per group: group 1 being the control group and groups 2, 3, and 4 being the experimental groups. Doses of super key 500 mg/kg, 1,000 mg/kg and 2,000 mg/kg were administered to the experimental groups, and a dose of normal saline solution, 10 mL/kg, was administered to the control group. We examined the survival rates, weights, clinical signs, gross findings and necropsy findings. This study was conducted under the approval of the Institutional Animal Ethics Committee. (Approval number: A01-14018).Results:No deaths or abnormalities occurred in any of the four groups. Although slight decreases in the weights of some female rats were noted, no significant changes in weights or differences in the gross findings between the control group and the experimental groups were observed. To check for abnormalities in organs, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs.Conclusion:The results of this research showed that administration of 500 ─ 2,000 mg/kg of super key did not cause any changes in the weights or in the results of necropsy examinations. Neither did it result in any mortalities. The above findings suggest that treatment with super key is relatively safe. Further studies on this subject are needed to yield more concrete evidence.

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“…The 22Rv1 cell line is an androgen-independent prostate cancer epithelial cell line that is representative of clinical recurrent prostate cancer [22]. Firstly, we examined the effect of AICAR on the growth of 22Rv1 prostate cancer cells.…”

Section: Resultsmentioning

confidence: 99%

AICAR induces apoptosis and inhibits migration of prostate cancer cells through an AMPK/mTOR-dependent pathway

Hsieh

Wang

et al. 2018

Preprint

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AICAR (5-aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types of cancers. However, the activity of AICAR on the cell growth and metastasis of prostate cancer has not been extensively studied. Herein we examine the effects of AICAR on the cell growth and metastasis of prostate cancer cells, 22RV1 cells. Cell growth was performed by MTT assay and soft agar assay. Cell apoptosis was examined by Annexin V/PI staining and PARP cleavage Western blot. Cell migration was evaluated by wound-healing assay. The expression of EMT-related protein and the activity of the AMPK/ mTOR-dependent pathway were analyzed by Western blot. In addition, we also tested the effect of AICAR on the chemosensitivity to docetaxel using MTT assay. Our results indicated that AICAR inhibits cell growth, induces apoptosis, attenuates TGF-β-induced cell migration and EMT-related protein expression, and enhances the chemosensitivity to docetaxel through regulating the AMPK/mTOR-dependent pathway. Collectively, these findings support AICAR as a potential therapeutic agent for the treatment of prostate cancer.

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Sulfur inhibits the growth of androgen-independent prostate cancer in vivo

Cited by 17 publications

References 23 publications

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats

AICAR induces apoptosis and inhibits migration of prostate cancer cells through an AMPK/mTOR-dependent pathway

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