Sulfur Halides

Precursors of Nerve Chemical Warfare Agents with Industrial Relevance: Characteristics and Significance for Chemical Security

“…SOCl 2 also reacts with amines and sulfamic acids with the sulfamyl chloride reaction products from sulfamic acids being important intermediates in the synthesis of some herbicides. SOCl 2 is also used as the electrolyte in high performance lithium‐SOCl 2 batteries . The significance of SOCl 2 is that it is used in the above mentioned “di‐di” method of manufacturing G‐type nerve agents.…”

Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation

“…Sulfuryl chloride is stated to behave as a source of chlorine gas, a compound that is known to promote α-chlorination. 8 Possibly HCl or Cl 2 is required for the transformation to take place, and a temperature rise might drive these out of the system. This is consistent with the decrease in yield as the reaction concentration increases because tight temperature control is more difficult to maintain.…”

“…There is a need to maintain headspace control and keep gases in solution; however, gases become less soluble as the temperature increases. Sulfuryl chloride is stated to behave as a source of chlorine gas, a compound that is known to promote α-chlorination . Possibly HCl or Cl 2 is required for the transformation to take place, and a temperature rise might drive these out of the system.…”

Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint Driven Innovation

“…Sulfuryl chloride is stated to behave as a source of chlorine gas, a compound which is known to promote α-chlorination. 8 Possibly HCl or Cl2 is the required for the transformation to take place, and temperature rise might drive these out of the system. This is consistent with decrease in yield as reaction concentration increases-tight temperature control is more difficult to maintain.…”