Sulfur fluoride exchange

Synthesis of Large Macrocycles with Chiral Sulfur Centers via Enantiospecific SuFEx and SuPhenEx Click Reactions

“…In this, we noted the potential of enantiospecific S­(VI) exchange reactions . Such reactions, like the sulfur–fluorine exchange (SuFEx) and sulfur–phenolate exchange (Su­Phen­Ex) click reactions, have become widely popular tools in synthetic chemistry for the synthesis of both small molecules, , biologically relevant molecules, , and new functional organic materials .…”

“…In this, we noted the potential of enantiospecific S(VI) exchange reactions. 16 Such reactions, like the sulfur−fluorine exchange (SuFEx) 17 and sulfur−phenolate exchange (SuPhen-Ex) 18 click reactions, have become widely popular tools in synthetic chemistry for the synthesis of both small molecules, 15f,19 biologically relevant molecules, 13c,20 and new functional organic materials. 21 Importantly, these reactions are highly efficient, resulting in high yields of the desired product, and they are often performed under mild conditions.…”

(Hetero)Aryl Fluorosulfates (ArOSO2F): Good Coupling Partners in Transition‐metal‐catalyzed Reactions

“…S−F bonds have S VI centers that are more stable than S−Cl bonds [14–17] . In addition, sulfuryl fluoride and fluorosulfates exhibit good reaction for click‐chemicals because they can only be activated under specific conditions [18–25] …”

“…[14][15][16][17] In addition, sulfuryl fluoride and fluorosulfates exhibit good reaction for click-chemicals because they can only be activated under specific conditions. [18][19][20][21][22][23][24][25] Fluorosulfates are primarily obtained in the presence of a base and sulfuryl fluoride gas from phenols, which have abundant natural sources and are often employed in drug modification and diversification. [13] Although this phenolic derivative was synthesized as early as the 20th century, [26][27][28][29][30] its potential in the field of chemistry has been occluded.…”

Radical Hydro-Fluorosulfonylation of Propargylic Alcohols via Electron Donor–Acceptor Photoactivation

“…Since Sharpless’ pioneer work on the declaration of sulfur­(VI) fluoride exchange (SuFEx) as the second generation of click chemistry in 2014, a variety of synthetic methods have been devised for sulfonyl fluoride installation, , including metal-catalyzed, photocatalytic, and electrochemical approaches . Recently, radical fluorosulfonylation has emerged as an attractive strategy for the preparation of functionalized sulfonyl fluorides .…”