Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats

Yang, Lefu; Zhang, Hui; Chen, Peili

doi:10.1016/j.niox.2018.09.005

Cited by 51 publications

(48 citation statements)

References 46 publications

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“…Cumulative evidences showed that the activation of NLRP3 inflammasome played a key role in sepsisinduced myocardial injury (Zhang et al, 2015;Wu et al, 2018). Yang et al (2018) also found that the expression levels of NLRP3 and caspase-1 were increased in myocardial tissue treated with cecal ligation and puncture. Consistent with these results, we also found that the expressions of NLRP3 and cleaved caspase-1 at the protein level in heart tissues and caspase-1 activity were increased by LPS.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, many studies have confirmed that NLRP3 inflammasome was activated in sepsis-induced multiple organ injury. Furthermore, suppression of NLRP3 inflammasome activation ameliorated SICD (Kalbitz et al, 2016;Yang et al, 2018). Moreover, it has been reported that silent information regulator 1 (SIRT1), an NAD+-dependent deacetylase that regulates various protein functions, plays a negative role in regulating the activation of NLRP3 inflammasome (Fu et al, 2013;Peng et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

et al. 2020

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Shikonin (SHI) is an anti-inflammatory agent extracted from natural herbs. It is still unknown whether SHI ameliorates lipopolysaccharide (LPS)-induced cardiac dysfunction. This study aims to explore the protective effects of SHI on LPS-induced myocardial injury and its mechanism. The LPS-induced cardiac dysfunction mouse model was employed to investigate the protective effects of SHI. In the present study, we found that SHI treatment improved the survival rate and cardiac function and remarkably ameliorated the release of inflammatory cytokines and macrophage infiltration in heart tissue of LPS-treated mice. SHI also reduced lactate dehydrogenase (LDH) and cardiac troponin (cTn) release, cell inflammation, and apoptosis in LPS plus adenosine triphosphate (ATP)-treated H9c2 cells. In addition, SHI significantly upregulated silent information regulator 1 (SIRT1) expression and suppressed the upregulation of NOD-like receptor protein 3 (NLRP3), cleaved caspase-1, and caspase-1 activity in heart tissues induced by LPS. Meanwhile, we got the same results in LPS plus ATP-treated H9c2 cells in vitro. Further, SIRT1 inhibitor or siRNA partially blocked SHI-mediated upregulation of SIRT1 expression and downregulation of NLRP3, cleaved caspase-1, and caspase-1 activity in heart tissues induced by LPS. Therefore, we conclude that SHI ameliorates LPS-induced cardiac dysfunction by inhibiting SIRT1-dependent activation of NLRP3 inflammasomes and might be a promising therapeutic strategy for the treatment of LPS-induced cardiac dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

et al. 2020

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“…There are many potential therapies being investigated in the laboratory setting, largely in animal models of septic cardiomyopathy. Potential therapies include statins, dexmedetomidine, hydrocortisone, alpha-2 blockers, yohimbine, Chinese yam, erythropoietin, vitamin c, and sulfur dioxide among others [85][86][87][88][89][90][91][92][93][94][95][96]. As these treatments transition from the bench to the bedside, potential therapeutic efficacy will need to be evaluated.…”

Section: Emerging Therapiesmentioning

confidence: 99%

Sepsis-Induced Cardiomyopathy: a Comprehensive Review

et al. 2020

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While sepsis-induced cardiomyopathy (SICM) has been recognized as a distinct entity since 1984, there are still no commonly agreed upon diagnostic criteria. This highlights a consequential gap in our collective medical knowledge with the potential to change patient outcomes. Purpose of Review To briefly review epidemiology and pathophysiology of SICM and provide a more extensive review of the data on diagnostic and management strategies. Recent Findings SICM is likely underdiagnosed and that has mortality implications. Current evidence supports speckle tracking echocardiography to identify decreased contractility irrespective of left ventricular ejection fraction for the diagnosis of SICM. There continues to be a dearth of large clinical trials evaluating the treatment of SICM and current consensus focuses on supportive measures such as vasopressors and inotropes. Summary Sepsis is a significant cause of mortality, and sepsis-induced cardiomyopathy has both prognostic and management implications for these patients. Individualized work-up and management of these patients is crucial to improving outcomes.

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“…Thus, the metabolites of COX-2 are involved in inflammatory disorders. Studies indicate that inhibition of COX-2 or soluble epoxidehydrolase is beneficial for inflammation [ 114 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ].…”

Section: Anti-inflammatory Molecules Of Medicinal Plants and Mechamentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

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Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats

Cited by 51 publications

References 46 publications

Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Sepsis-Induced Cardiomyopathy: a Comprehensive Review

Plants as Sources of Anti-Inflammatory Agents

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