Sulfur-containing gaseous signaling molecules

Sukmansky, Oleg I.

doi:10.15407/fz63.06.106

Cited by 4 publications

(5 citation statements)

References 87 publications

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“…В останні десятиліття відкрита низка фундаментальних явищ, механізмів і структур, властивих основним царствам живих істот -тварин, рослин і мікроорганізмів, що знову підтверджує спільність їхнього походження і розвиток шляхом еволюції. До їх числа слід віднести водні канали -аквапорини [7,8], систему захисту і репарації білківшаперони [9], механізми активації вродженого імунітету за допомогою паттерн-розпізнавальних рецепторів [10,11] і нову систему біорегуляторів -газові сигнальні молекули (ГСМ) [12,13,14]. Недарма відкриття ГСМ, аквапоринів і механізмів активації вродженого імунітету були відзначені Нобелівськими преміями.…”

Section: відомості про авторів Information About Authorsunclassified

“…Недарма відкриття ГСМ, аквапоринів і механізмів активації вродженого імунітету були відзначені Нобелівськими преміями. Газові сигнальні молекули (газові медіатори або газотрансмітери) -це ендогенні (синтезовані в організмі) невеликі молекули газів, які виконують у клітинах сигнальну функцію і беруть участь у міжклітинній та внутрішньоклітинній комунікації [12,13,14]. На рівні цілого організму вони виконують функцію біорегуляторів з ендокринною, паракринною та автокринною дією [12].…”

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“…Оскільки ГСМ людини і ссавців описані нами у кількох попередніх публікаціях [12,13,14], у цій статті ми обмежи-мось наведенням таблиці, яка узагальнює основні дані про ГСМ ссавців та коротким резюме.…”

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Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review)

Sukmansky¹

2019

Journal NAMSU

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Data, presented in this review, show that gaseous signaling molecules are a common biological system of bioregulators, which attribute to main kingdoms of life – animals, plants and bacteria. They confirm the similarity of their origin and developing by evolution. Gaseous signaling molecules (gasotransmitters) were first discovered and mostly researched in humans and mammals. Today are known gaseous signaling molecules such as: nitric oxide and reactive oxygen species, carbon monoxide, hydrogen sulfide, polysulfides and sulfur dioxide. It is proved that there are more gaseous signaling molecules and more pathways and mechanisms of their production in bacteria than in mammals, so their importance in evolution of living organisms on the planet Earth has decreased. However, in the process of evolution, in connection with the development from simple unicellular organisms into complex, higher multicellular, the number of functional targets that were influenced by gaseous signaling molecules has increased, i.e. their role has been getting increasingly complicated. The endogenous gaseous signaling molecules, produced by bacteria, regulate their metabolism, protect them against antibiotics and promote their colonization in the host organism. So they play an important role in the pathogenesis of infectious diseases in humans and animals. On the other side, the endogenous gaseous signaling molecules of humans and animals have mostly the negative impact on bacteria’s development and increase the host’s resistance to infections. Published data prove the similarity of function and role in pathology of gaseous signaling molecules in invertebrates with those in higher (vertebrate) animals. In particular, this relates to the nervous system and to the role of gaseous signaling molecules in the formation of memory and behavior. The gaseous signaling molecules of non-mammal vertebrata – fishes, amphibians, reptiles, and birds – are especially similar to mammals and humans. Isolated tissues of brain, eyes and lungs of poikilothermic non-mammalian vertebrates (fishes, amphibians and reptiles) are used to study the possible role of gaseous signaling molecules in the pathogenesis of diseases affecting these organs in humans. Further researches of the evolution of gaseous signaling molecules by comparing them in living beings of different levels of development may be useful for exposure of new ways of application in medicine and adjacent fields. The study of their role in the pathogenesis of pathological processes increases the possibilities of treatment and prevention of diseases via utilization of gaseous signaling molecules, their donors, precursors, and inhibitors. Key words: gaseous signaling molecules, evolution, vertebrate, invertebrate, bacteria, biological action, role in pathology. For citation: Sukmansky OI. Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review). Journal of the National Academy of Medical Sciences of Ukraine. 2019;25(4):373–382

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Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review)

Sukmansky¹

2019

Journal NAMSU

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“…2 The main effects of H 2 S are neuromodulation, regulation of vascular tone, cytoprotection, anti-inflammatory action, sensing (reception) of oxygen, angiogenesis and energy generation. [3][4] Enzymatic formation of H 2 S is catalyzed by cystathionine γ-lyase (EC 4.4.1.1, CSE), cystathionine β-synthase (EC 4.2.1.22, CBS) and 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2, MST). 5 All these three enzymes are present in the liver and through the synthesis of H 2 S regulate its functions.…”

Section: Introductionmentioning

confidence: 99%

Role of sulfide anion in the development of chronic alcoholic hepatitis under the conditions of modulation of adenosine monophosphate kinase – a correlational study

Mykytenko,

Akimov,

Shevchenko

et al. 2023

Eur J Clin Exp Med

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Introduction and aim. Hydrogen sulfide (H 2 S) has attracted the attention of researchers as a novel signaling molecule that affects vascular metabolism, immune function, stress and inflammation. It plays an important role in pathophysiological disorders under the conditions of the development of obesity, diabetes, non-alcoholic fatty liver disease and cardiovascular diseases. The purpose of this work is to establish correlation ratios of H 2 S concentration with markers of oxidative-nitrosative stress and extracellular matrix metabolism of the liver during chronic alcoholic hepatitis modeling and AMPK modulation by phenformin and doxorubicin. Material and methods. The experiments were performed on 36 white, sexually mature male Wistar rats, weighing 180-220 g. Alcoholic hepatitis was modelled by alcohol administration, on the background of alcoholic hepatitis animals received phenformin orally at a dose of 10 mg/kg or doxorubicin at a dose of 1.25 mg/kg intraperitoneally. Statistical processing of the results of biochemical studies was carried out using the non-parametric method of Spearman to determine correlations. Results. H 2 S during alcoholic hepatitis inversely proportionally strongly correlates with the concentration of nitrites, oxyproline and arginase activity. Phenformin administration during alcoholic hepatitis leads to formation of inversely proportionally strongly correlation of H 2 S with the production of superoxide anion radical, the concentration of malondialdehyde, activities of constitutive NO-synthases, nitrite reductases, nitrate reductases, and arginase. Doxorubicin administration during alcoholic hepatitis leads to formation of directly proportional strongly correlation of H 2 S with the activity of constitutive NO-synthases, nitrite reductases, nitrate reductases. Conclusion. Administration of phenformin or doxorubicin expands correlations between H 2 S and indicators of oxidative-nitrosative stress.

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“…[3,4,29]. Hydrogen sulfide has also been shown to have antioxidant and antiapoptotic properties [26].…”

Section: Introductionmentioning

confidence: 99%

The influence of hydrogen sulfide on the structural characteristics of leukocytes mitochondrial apparatus in patients with arterial hypertension

Kravchuk

Rozova

2019

Rep. of Morph.

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One of the leading causes of arterial hypertension (AH) is mitochondrial dysfunction (MD) – moreover, disorders in regulation of blood pressure occur on the background of progressive energy deficiency. At the same time, the cardioprotective effect of H2S has been proven. In particular, the inhibition of mitochondrial pore opening by hydrogen sulfide plays an important role, and H2S should affect the structural component of MD, namely, the ultrastructure of mitochondria. However, at present, the question of structural changes in the mitochondrial apparatus in patients with hypertension is extremely insufficiently studied. For the study of MD in healthy people and patients with pathology, almost the only objects (in the absence of surgical intervention) are blood cells, in particular leukocytes. Based on the above, the aim of the study was to investigate the effect of a hydrogen sulfide donor on the ultrastructure of the mitochondrial apparatus of leukocytes in patients with arterial hypertension. The effect of a hydrogen sulfide donor on some ultrastructural characteristics of the leukocyte mitochondrial apparatus in patients with hypertension was studied. The examination involved patients (men) with arterial hypertension aged 30-60 years, who were divided into 2 age groups: 30-40 and 40-60 years. Control groups (healthy men without signs of hypertension) were randomized by age. An electron microscopic and morphometric assessment of the structure of mitochondria revealed that under hypertension it undergoes significant changes that depend on the age of the patients. It has been established that the addition of a hydrogen sulfide donor (Full Spectrum Garlic phytopreparation (Swanson Health Products, USA) at a dose of 400 mg per day) to the traditional therapy of hypertension leads to positive changes in the mitochondrial ultrastructure of the studied cells aimed at increasing the energy capacity of the mitochondrial apparatus – the quantity reduction of structurally damaged mitochondria, and with an increase in the duration of treatment – the increase their total number in people of the younger age group (by 57.5%), and in the older age group – by 53.7%. Thus, the indicated effect of H2S significantly depends both on the age of the patients (young people respond more intensively) and on the duration of the hydrogen sulfide donor using (long-term use is accompanied by a more pronounced positive dynamics of changes).

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Sulfur-containing gaseous signaling molecules

Cited by 4 publications

References 87 publications

Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review)

Gaseous signaling molecules (GSM): evolution, biological role and involvement in the pathogenesis of diseases (literature review)

Role of sulfide anion in the development of chronic alcoholic hepatitis under the conditions of modulation of adenosine monophosphate kinase – a correlational study

The influence of hydrogen sulfide on the structural characteristics of leukocytes mitochondrial apparatus in patients with arterial hypertension

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