Sulfur‐containing gaseous signal molecules, ion channels and cardiovascular diseases

Wen, Yongning; Jin, Hongfang; Tang, Chaoshu; Du, Junbao; Zhang, Zhiren

doi:10.1111/bph.13829

Cited by 36 publications

(11 citation statements)

References 86 publications

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“…A few studies have investigated the relationships between atmospheric SO 2 and neurological dysfunction [ 16 , 41 ]. Several studies have reported the effect of SO 2 on the cardiovascular system [ 42 , 43 ], however few studies have reported the effect on the CNS. Hippocampal synaptic dysfunction due to SO 2 exposure has been reported, and this may play a role in cognitive impairment [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Air Pollution Is Associated with Poor Cognitive Function in Taiwanese Adults

Chen

Wang

Lai

et al. 2021

IJERPH

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The issue of air pollution is gaining increasing attention worldwide, and mounting evidence has shown an association between air pollution and cognitive decline. The aim of this study was to investigate the relationships between air pollutants and cognitive impairment using the Mini-Mental State Exam (MMSE) and its sub-domains. In this study, we used data from the Taiwan Biobank combined with detailed daily data on air pollution. Cognitive function was assessed using the MMSE and its five subgroups of cognitive functioning. After multivariable linear regression analysis, a high level of particulate matter with an aerodynamic diameter of ≤2.5 μm (PM2.5), low ozone (O3), high carbon monoxide (CO), high sulfur dioxide (SO2), high nitric oxide (NO), high nitrogen dioxide (NO2), and high nitrogen oxide (NOx) were significantly associated with low total MMSE scores. Further, high SO2 and low O3 were significantly associated with low MMSE G1 scores. Low O3, high CO, high SO2, high NO2, and high NOx were significantly associated with low MMSE G4 scores, and high PM2.5, high particulate matter with an aerodynamic diameter of ≤10 μm (PM10), high SO2, high NO2, and high NOx were significantly associated with low MMSE G5 scores. Our results showed that exposure to different air pollutants may lead to general cognitive decline and impairment of specific domains of cognitive functioning, and O3 may be a protective factor. These findings may be helpful in the development of policies regarding the regulation of air pollution.

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Section: Discussionmentioning

confidence: 99%

Air Pollution Is Associated with Poor Cognitive Function in Taiwanese Adults

Chen

Wang

Lai

et al. 2021

IJERPH

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“…It is well established that within the vasculature hydrogen sulfide (H2S) acts as an endogenous vasodilating mediator (Cirino et al, 2017). Several molecular targets have been identified such as potassium channels (i.e ATP-calcium-voltage gateddependent) (Yu et al, 2018;Zhao et al, 2001;Zuidema et al, 2010), transient receptor potential and chloride and sodium channels (Yu et al, 2018), phosphodiesterases (PDE) (Bucci et al, 2010;Coletta et al, 2012) and phospholipase A2 (d'Emmanuele di Villa Bianca et al, 2011;di Villa Bianca et al, 2010). H2S is endogenously generated by three constitutive enzymes: cystathionine γ-lyase (CSE) and cystathionine βsynthase (CBS), that both use L-cysteine as substrate and require pyridoxal 5' phosphate (PLP) as a co-factor.…”

Section: Introductionmentioning

confidence: 99%

Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone

Mitidieri

Vellecco

Brancaleone

et al. 2021

British J Pharmacology

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Background and Purpose: L-cysteine or hydrogen sulfide (H 2 S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30-100 μM.Here, we have investigated the signalling involved in the H 2 S-induced contraction. Experimental Approach: Vascular response to NaHS or L-cysteine is evaluated on isolated precontracted with phenylephrine vessel rings harvested from wild type, cystathionine γ-lyase (CSE À /À ), soluble guanylyl cyclase (sGC α1 À /À ) and endothelial nitric oxide synthase (eNOS À/À ) knock-out mice. The cAMP, cGMP and inosine 3 0 ,5 0 -cyclic monophosphate (cIMP) levels are simultaneously quantified using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. The involvement of sGC, phosphodiesterase (PDE) 4A and PDE5 are also evaluated. Key Results: CSE-derived H 2 S-induced contraction requires an intact eNOS/NO/ sGC pathway and involves cIMP as a second messenger. H 2 S contractile effect involves a transient increase of cGMP and cAMP metabolism caused by PDE5 and PDE4A, thus unmasking cIMP contracting action. The stable cell-permeable analogue of cIMP elicits concentration-dependent contraction on a stable background tone induced by phenylephrine. The lack of cIMP, coupled to the hypocontractility Abbreviations: 3-MST, 3-mercaptopyruvate sulfur transferase; CAT, cysteine aspartate aminotransferase; CBS, cystathionine-β-synthase; cIMP, inosine 3 0 ,5 0 -cyclic monophosphate; cNMP, nucleotide cyclic monophosphate; CSE, cystathionine γ-lyase; ET-1, endothelin-1; ETA, endothelin-1 receptor A; ETB, endothelin-1 receptor B; H2S, hydrogen sulfide; ITP, inosine triphosphate; PLP, pyridoxal-5 0 -phosphate; UPLC, ultra-performing liquid chromatography. Emma Mitidieri and Valentina Vellecco equally contributed. Roberta d'Emmanuele di Villa Bianca and Mariarosaria Bucci equally contributed.

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“…Researchers find H 2 S inhibits deposition of calcium in ECM, suppresses osteoblast trans-differentiation and calcification of VSMCs [20] , regulates K ATP channels to relax vascular smooth muscles and reduces expression of mitogen-activated protein kinase (MAPK) to inhibit proliferation of VSMCs [21] , [22] . H 2 S inhibits phosphorylation of STAT3 and expression of Jak to improve LPS-induced disorders of iron metabolism [23] .…”

Section: Introductionmentioning

confidence: 99%

Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling

Tian

Teng

Jin

et al. 2021

Journal of Advanced Research

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Sulfur‐containing gaseous signal molecules, ion channels and cardiovascular diseases

Abstract: This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.

Cited by 36 publications

References 86 publications

Air Pollution Is Associated with Poor Cognitive Function in Taiwanese Adults

Air Pollution Is Associated with Poor Cognitive Function in Taiwanese Adults

Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone

Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling

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