Sulfur-Containing Compounds from Endophytic Fungi: Sources, Structures and Bioactivities

Fan, Yaqin; Ma, Zhenqiang; Zhang, Yan; Wang, Yufei; Ding, Yousong; Cao, Shugeng

doi:10.3390/jof8060628

Cited by 7 publications

(3 citation statements)

References 68 publications

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“…The endophytic fungus is now serving as a promisingly strategic natural bioresource for the discovery of novel natural products with interesting chemical structures and versatile biological activities (Fan et al, 2022 ). In particular, it was well-respected as a treasure house for developing novel antibacterial agents (Cruz et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Isolation, identification, and antibacterial evaluation of endophytic fungi from Gannan navel orange

et al. 2023

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Gannan navel orange is a famous brand in China but the isolation of its endophytic fungi was rarely reported. In this study, a total of 54 strains of endophytic fungi were successfully isolated from the pulp, peel, twig, and leaf of Gannan navel orange; they were successfully identified to belong to 17 species of 12 genera. All these strains were fermented using potato-dextrose agar (PDA) medium, and their secondary metabolites were then extracted with ethyl acetate (EtOAc). The antibacterial assays of Escherichia coli (E. coli), methicillin-resistant Staphylococcus aureus (MRSA), and Xanthomonas citri subsp. citri (Xcc) were also performed for the EtOAc extracts of these strains. As a result, the extracts of both Geotrichum sp. (gc-1-127-30) and Diaporthe biconispora (gc-1-128-79) demonstrated significant antibacterial activities against Xcc, and the MIC value for the extract of Colletotrichum gloeosporioides against MRSA was low to 62.5 μg/mL. Moreover, the chemical components of the extracts of Colletotrichum sp., Diaporthe biconispora, and Annulohypoxylon atroroseum were primarily investigated, and they successfully led to the isolation of 24 compounds involving a new botryane sesquiterpene. Among the isolated products, compound 2 showed significant inhibitory activities toward SA, MRSA, E. coli, and Xcc with MIC values of 12.5, 3.1, 125, and 12.5 μg/mL, respectively. This study revealed that the endophytic fungi of Gannan navel orange showed high potency to produce secondary metabolites with significant antibacterial effects.

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Section: Introductionmentioning

confidence: 99%

Isolation, identification, and antibacterial evaluation of endophytic fungi from Gannan navel orange

et al. 2023

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“…The endophytic fungus has now be considered auspiciously deliberate natural bioresource for the innovations of novel phytochemicals with diverse chemical moieties and flexible therapeutic applications (Fan et al, 2022). Further , it has been reported that it is rich deposits of house for discovering novel antibacterial compounds (Cruz et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Isolation, Morphological And Biochemical Identification Of Endophytic Fungi From Moringa oleifera And Its Antimicrobial Potential

Kumar,

Awasthi

2022

SFS

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The present study was aimed at isolating endophytic fungi from the leaves of M. oleifera and analyzing its antimicrobial potential. In this study, the fungal endophyte Acremonium sp. was isolated identified through morphological and biochemical analysis. In IAA the strain produced 55.27 ± 3.00 μgml-1 IAA without exogenous tryptophan application (control) in the culture medium. The addition of 1mgml-1 tryptophan to the culture medium increased the IAA production to 76 ± 2.6 μgml-1 The production of siderophore was performed in the absence and presence of an iron source in the medium. The strain was cultured in the minimal media supplemented with different Fe(III) citrate concentrations, i.e., 0 μM, 0.25 μM, 2.0 μM, and 4.0 μM. The isolated fungi showed high siderophore production when cultured in a medium without Fe(III) citrate. Siderophore production found to be 40.00 ± 0.4 (psu) in the culture medium without the addition of Fe(III) citrate.. Siderophore production was slightly reduced , i.e., 33 ± 0.3 (psu) at 0.25 μM Fe(III) citrate in the culture medium. However, a significant reduction in the production of the siderophore was observed when Fe (III) citrate content was raised to 2.0 μM and 4.0 μM. In case of bacterial strains it was observed that maximum activity was observed against P. aeruginosa at 80 µg/ml (IZ-20mm) while minimum at 20 µg/ml against E. coli (10mm) but at 40 and 60 µg/ml activity was at par (IZ-14mm) while S. aureus was found to be partially resistant. In case of antifungal it was observed that when extract of PD 20 was tested maximum activity was observed at 80 µg/ml against T. reesei (IZ-22mm) while C. albicans was found to be partially resistant as initially no activity was observed against it. Against P. funiculosum no activity was observed at 20 µg/ml but with increase dose level activity increased.Therefore, we conclude that the isolated Acremonium sp. should be further investigated before utilization as a biocontrol agent and plant growth stimulator

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“…Fan et al reported 143 new sulfur-containing compounds that were reported from 1985 to 2022 and their fungal producers, plant sources, chemical structures, and bioactivities. These natural products mainly belong to the classes of polyketides, nonribosomal peptides, terpenoids, and hybrids [42].…”

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confidence: 99%

Secondary Metabolites from Fungi—In Honor of Prof. Dr. Ji-Kai Liu’s 60th Birthday

Feng

Surup

2022

JoF

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Sulfur-Containing Compounds from Endophytic Fungi: Sources, Structures and Bioactivities

Cited by 7 publications

References 68 publications

Isolation, identification, and antibacterial evaluation of endophytic fungi from Gannan navel orange

Isolation, identification, and antibacterial evaluation of endophytic fungi from Gannan navel orange

Isolation, Morphological And Biochemical Identification Of Endophytic Fungi From Moringa oleifera And Its Antimicrobial Potential

Secondary Metabolites from Fungi—In Honor of Prof. Dr. Ji-Kai Liu’s 60th Birthday

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