Sulfur bentonite‐organic‐based fertilizers as tool for improving bio‐compounds with antioxidant activities in red onion

Muscolo, Adele; Papalia, Teresa; Settineri, Giovanna; Mallamaci, Carmelo; Panuccio, Maria Rosaria

doi:10.1002/jsfa.10086

Cited by 13 publications

(25 citation statements)

References 61 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyphenols are produced as secondary metabolites of plants due to their self-protection properties, and are abundantly contained in seeds, leaves, stems, and fruits of plants [ 6 ]. Polyphenols are known to have physiological activities such as antioxidant, anti-inflammatory, antiviral, antibacterial, and anticancer [ 7 ]. The polyphenols inhibit cancer cell proliferation, eliminate cancer cells through signaling pathways, and contribute to various mechanisms that induce cell cycle and apoptosis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Cellular Regulation of Kynurenic Acid-Induced Cell Apoptosis Pathways in AGS Cells

Kim

Jeong²,

Ha³

et al. 2022

IJMS

View full text Add to dashboard Buy / Rent full text

Kynurenic acid was included in the three compounds (caffeic acid, chlorogenic acid, and kynurenic acid) that showed high antioxidant and anti-inflammatory potential among the phenolic compounds contained in Gynura procumbens. In this study, the mechanism of cancer cell death induced by kynurenic acid (KYNA), which has the highest molecular binding affinity, in the gastric cancer cell line AGS was confirmed in molecular docking analysis. KYNA showed the most cancer cell death effect on AGS cells among several gastric cancer cell lines (MKN, AGS, and SNU). AGS cells were used for later experiments, and KYNA concentrations of 0, 150, 200, and 250 µM were used. KYNA inhibited cell migration and proliferation in AGS cells in a concentration-dependent manner. G2/M phase cell cycle arrest and reduction of related proteins (Cdc25C, CDK1 and CyclinB1) were confirmed in KYNA-treated AGS cells. Apoptosis of KYNA-treated AGS cells was confirmed by Annexin V/propidium iodide (PI) staining flow cytometry analysis. As a result of morphological chromatin condensation through DAPI (4′,6-diamidino-2-phenylindole), intense blue fluorescence was confirmed. The mechanism of apoptosis induction of KYNA-treated AGS cells was confirmed by western blotting. In the extrinsic pathway, apoptosis induction markers FasL, Fas, and Caspase-3 and -8 were increased in a concentration-dependent manner upon KYNA treatment. In the intrinsic pathway, the expression of anti-apoptotic factors PI3K, AKT, and Bcl-xL was down-regulated, and the expression of apoptosis-inducing factors BAD, Bak, Bax, Cytochrom C, and Caspase-9 was up-regulated. Therefore, in the present study, we strongly imply that KYNA induces apoptosis in AGS gastric cancer cells. This suggests that KYNA, a natural compound, could be the basis for drug for the treatment of gastric cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Cellular Regulation of Kynurenic Acid-Induced Cell Apoptosis Pathways in AGS Cells

Kim

Jeong²,

Ha³

et al. 2022

IJMS

View full text Add to dashboard Buy / Rent full text

show abstract

“…Assessment of Phenolic Compounds in Bulb: Total phenol content was detected by the Folin-Ciocalteu assay adapted to assess monomeric phenols and polyphenols red onion. [37] The absorbance of each sample was recorded at 760 nm using a UV-1800 high-resolution spectrophotometer (Shimadzu, Kyoto, Japan). A calibration curve was constructed using gallic acid and results were expressed as micrograms of tannic acid per gram DW.…”

Section: Methodsmentioning

confidence: 99%

AnchoisFert: A New Organic Fertilizer from Fish Processing Waste for Sustainable Agriculture

et al. 2022

Self Cite

View full text Add to dashboard Buy / Rent full text

The "AnchoisFert" solid residue comprised of milled anchovy leftovers after fish oil extraction with biobased limonene is a powerful organic fertilizer. Employed to promote the growth of Tropea's red onion (Allium cepa), the fertilizer turns out to largely superior to commonly used organic (manure) and chemical (NPK) fertilizers. Rich in proteins, organic carbon, flavonoids, magnesium, potassium, phosphate and sulphate, and devoid of antibiotics and antibiotic resistance genes, the new organic fertilizer can replace both conventional organic and inorganic fertilizers. The discovery closes the fishing material cycle for one of the most fished species across the seas opening the route to a new class of organic fertilizers of exceptional performance derived from abundant biowaste via a low-cost, environmentally-friendly circular economy process.

show abstract

“…Total phenol content was determined with the Folin-Ciocalteu reagent according to Muscolo et al [25]. Briefly, 500 µl of the aqueous extract was mixed with 250 µl of Folin-Ciocalteu reagent and 2 ml of a 20% Na2CO3 aqueous solution, the mixture was filled up to 50 ml with deionised water and placed in the dark for 1 h. The absorbance was measured at 765 nm using a UV-Vis Agilent 8453 spectrophotometer (Agilent Technologies, CA USA).…”

Section: Determination Of Total Phenolic Compounds Total Flavonoids V...mentioning

confidence: 99%

Pomegranate Biowastes Are Rich in Valuable Bioactive-Compounds With Potential Benefit on Human Health

Marra¹,

Petrovicova²,

Canino³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Buy / Rent full text

Pomegranate use is increasing worldwide as it is considered a tasteful healthy food. It is mainly used as fruit, juice and jam. The pomegranate peel represents about 40-50% of the total fruit weight and contains numerous and diverse bioactive substances. The aim of this research was to analyse the pomegranate peel composition of Wonderful cultivated in Southern Italy and treated with an innovative physic dry concentration procedure. The aim was to verify how the drying process influenced the bioactive compounds that could be used as nutraceuticals. A comparison with the peel composition of freeze dried Wonderful cultivated in Southern Italy, freeze dried Wonderful cultivated in South Africa and freeze-dried pomegranate Kullu and Himachal cultivated in India has been done. Results evidenced that in pomegranate peels of Wonderful cultivated in Calabria and dried with the innovative process, total phenolic substances, total flavonoids, vitamin C, vitamin E and antioxidant activities, were the highest. Great amounts of single phenolic acids and flavonoids were found in Calabrian Wonderful peels dried with the innovative process. Overall, it emerged that the great amount of bioactive and diverse compounds found in Calabrian Wonderful pomegranate peel, come from the niche pedoclimatic conditions, and the physic drying innovative methodology.

show abstract

Sulfur bentonite‐organic‐based fertilizers as tool for improving bio‐compounds with antioxidant activities in red onion

Cited by 13 publications

References 61 publications

Cellular Regulation of Kynurenic Acid-Induced Cell Apoptosis Pathways in AGS Cells

Cellular Regulation of Kynurenic Acid-Induced Cell Apoptosis Pathways in AGS Cells

AnchoisFert: A New Organic Fertilizer from Fish Processing Waste for Sustainable Agriculture

Pomegranate Biowastes Are Rich in Valuable Bioactive-Compounds With Potential Benefit on Human Health

Contact Info

Product

Resources

About