Sulfoxide synthesis from sulfinate esters under Pummerer-like conditions

Abstract

A facile synthetic method of allyl sulfoxides by S-allylation of sulfinate esters proceeds through sulfonium intermediates. On the basis of the plausible reaction mechanism, S-alkynylation and S-arylation were also accomplished.

o-Silylaryl Triflates: A Journey of Kobayashi Aryne Precursors

“…In this study, both N-unprotected and N-Boc-protected analogues of these three types of indolynes as well as 3-substituted 4,5-indolyne precursors were also prepared . Moreover, direct functionalization on the framework of indolyne precursors was demonstrated by the groups of Pilarski , and Yoshida …”

Dietary Patterns and Progression of Impaired Kidney Function in Japanese Adults: A Longitudinal Analysis for the Fukushima Health Management Survey, 2011–2015

“…We calculated the annual eGFR change rate by the differences between baseline and final measurements and divided them by the follow-up time [36]. In the trajectory analysis for eGFR changes over time, the participants were classified into 3 groups: the group in which the eGFR level decreased most was defined as the early decliner group [37].…”

“…We applied the multiple linear regression model to measure the annual eGFR decline rate associated with dietary patterns. Finally, we performed a polytomous logistic regression analysis to examine the association between dietary pattern scores and groups of eGFR decliners, using the moderate lowering eGFR group as a reference [36]. We input the tertiles of each dietary pattern score simultaneously in the model, and the associations with outcomes were adjusted for age (continuous) and sex (Model 1); further adjustments were made for education, smoking history, alcohol consumption, physical activity, resident status, distress scale, BMI, diabetes, hypertension, and dyslipidemia by categories as mentioned above (Model 2).…”

Direct Synthesis of Sulfinylated Benzofulvenes via BF3·Et2O-Promoted Cascade Reactions of Arylsulfinic Acids with 1,3-Enynes

“…In addition, sulfoxides are often used as ligands in transition-metal catalysis, organocatalysts in asymmetric reactions, and intermediates in organic transformations . Because of their significance in organic synthesis and medicinal chemistry, a variety of useful methods have been demonstrated for sulfoxide synthesis, including the oxidation of corresponding sulfides, nucleophilic substitution of sulfinate amides or esters with organometallic reagents, and transition-metal-catalyzed cross-coupling reactions of sulfenate anions and aryl halogens or arylborons . However, to our knowledge, an example of the introduction of sulfoxide moieties into benzofulvene frameworks still remains unexplored.…”