Sulfosalicylic acid/Fe³⁺ based nanoscale coordination polymers for effective cancer therapy by the Fenton reaction: an inspiration for understanding the role of aspirin in the prevention of cancer

Abstract

A new type of pH-responsive nanoscale coordination polymer for ROS-enhanced cancer therapy.

Urine metabonomic study on primary liver cancer with spleen deficiency and excess dampness syndrome based on ultra-performance LC-MS

“…The criteria of VIP > 1, |log2(FC)| > 2, and P-value < 0.05 were used to compare the differential metabolites in untreated patients with those in healthy people or in IPED-treatment patients. The finding of norethisterone acetate, a synthetic derivative of progestogen commonly used in therapy for contraception and ovulation inhibition, and sulfosalicylic acid, a derivative of salicylic acid that acts as a chelating agent for iron ions [23], suggests that patients with PLC-SDES may have a risk of exposure to drug residues, since neither of these two compounds can be synthesized by the human body.…”

Controllable synthesis of variable-sized magnetic nanocrystals self-assembled into porous nanostructures for enhanced cancer chemo-ferroptosis therapy and MR imaging

“…In particular, the iron-catalyzed ROS production pathway (called as Fenton reaction) has been widely accepted. [24][25][26] Using the key role of iron in ferroptosis, various iron-based nanostructures have been developed for ferroptosis-inducing cancer therapy, [27][28][29] such as Fe 3 O 4 , [30][31][32][33][34] g-Fe 2 O 3 , 35 FePt, 36 Fe 3+ /polymer, [37][38][39][40][41] Iron-MOF, 42,43 FeS 2 -PEG 44 and oxide iron-based nanocomposites. [45][46][47] More importantly, Mn(0.25)-Fe 3 O 4 -III NPs act as Fenton agents, which show extremely high Fenton reaction activity compared with numerous reported iron-based nanoparticles.…”

Coordination Polymers Integrating Metalloimmunology with Immune Modulation to Elicit Robust Cancer Chemoimmunotherapy

“…24,25 Previous studies have focused on the physicochemical property of metal unit in coordination polymers, such as magnetic properties for MRI imaging and Fenton activity for chemo-dynamic therapy. [26][27][28][29] However, metal ions detached from the intrinsically biodegradable coordination polymers would also take part in life processes, especially the immune system. [30][31][32] For instance, it has recently been reported that manganese ions and zinc ions could greatly enhance the Cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, and subsequently triggers multifaceted type I interferon-driven inflammatory responses to activate innate immune.…”