Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ

Zhang, Jian; Dong, Yanyan; Zhou, Miaomiao; Wo, Xiaoman; Niu, Sunmin; Shao, Enze; Xue, Lingui; Jin, Hongbo; Zhao, Wenran

doi:10.1016/j.bbrc.2022.03.015

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…SFN was originally identi ed as a dietary isothiocyanate. It has been reported to have bene cial effects in many disease states, including neurological disorders, skin diseases, respiratory diseases and cancers.In recent years, more and more studies have found that SFN could protect myocardium in many cardiac diseases (myocardium I/R injury [20], diabetic cardiomyopathy[18], chronic heart failure [43], etc. ).…”

Section: Discussionmentioning

confidence: 99%

“…SFN is known to exert antioxidant [16], anti-in ammatory [17], and anti-apoptotic effects [18]. The protective effect of SFN against cardiac injury has also been documented [19][20][21]. It has been reported that SFN protected aortic smooth muscle and cardiomyocytes from oxidative stress injury in myocardium ischemia reperfusion (I/R) rats [22].…”

Section: Introductionmentioning

confidence: 99%

“…Rats pretreated with SFN or fed with broccoli have been reported to decrease infarct size in I/R heart [23]. In all studies on SFN treatment for I/R injury, the drug was given before ischemia [20,[22][23][24][25][26][27][28][29][30]. However, in clinical practice, the time point to treat I/R injury is usually after ischemia.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, considering the treatment drugs for MI patients having adverse effects, SFN was tested as a new drug for MI due to its myocardium protective effect [19][20][21], low toxicity and easy absorption [20]. Meanwhile, the therapeutic drugs could not reach the lesion area in the su cient concentration due to coronary artery occlusion in MI.…”

Section: Introductionmentioning

confidence: 99%

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Porous magnetic Silica nanoparticles loaded with sulforaphane mitigate myocardial infarction injury through upregulating HSP70

Zhang

Dong

et al. 2022

Preprint

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Myocardial infarction (MI) is a common cardiovascular disease that induces an extensive sterile inflammation in the early stage, but usually seriously endangers human health. The modulation of cardiac inflammation may improve the outcome of post MI. Unfortunately, due to therapeutic drugs’ side effects and the cardiac coronary artery occlusion, currently MI drugs always can hardly fulfill the myocardial ischemia environment and clinical requirements. Considering the myocardial protective effect and low toxicity of sulforaphane (SFN), SFN was adopted for the treatment of MI. However, it is still difficult for the targeted accumulation of SFN in the infarcted area. Herein, porous magnetic silica nanoparticles (PMSNs) were synthesized and loaded with sulforaphane (SFN) to improve the efficiency by targeted delivery to the infarcted area in MI mice. PMSNs loaded with SFN (PMSNs+SFN) decreased the pro-inflammatory cytokines, thus improving the cardiac functions and cell survival without any adverse effects. To further explore the mechanism by which SFN treated MI mice, oxygen and glucose deprivation (OGD) cells was established as a cellular model for the in vitro study of MI. Knockdown of HSF1 or Nrf2 decreased SFN-induced HSP70 in the OGD cells. Moreover, knockdown of HSP70 blocked the pro-survival and anti-inflammatory effect of SFN for OGD cells. Moreover, HSP70 overexpression was sufficient to decrease pro-inflammatory cytokines and improve cell survival under OGD. Taken together, PMSNs transported sufficient SFN to the infarcted area in MI. We demonstrated that SFN exerted cardioprotective effect toward MI injury by up-regulating HSP70 through Nrf2/HSF1.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Porous magnetic Silica nanoparticles loaded with sulforaphane mitigate myocardial infarction injury through upregulating HSP70

Zhang

Dong

et al. 2022

Preprint

Self Cite

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“…In a study conducted by Zhang et al (2022), SFN increased cardiac function and cardiomyocyte survival in mice with induced cardiac ischemia. This cardioprotective effect was achieved by inhibiting the expression of the CAMK2D gene (which encodes the structure of the protein CaMKIIδ, whose reduced activity protects the heart from ischemic damage) and inducing gene expression for the CaMKIIN2 protein, which inhibits CaMKIIδ [61]. Bai et al (2017) indicated that SFN may have a protective effect on cardiac function through activation of Nrf2, inhibiting myocardial hypertrophy and fibrosis, inflammation, and oxidative stress [62].…”

Section: Cardiovascular-protective Effectsmentioning

confidence: 99%

Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies

Baralić,

Živanović,

Marić

et al. 2024

Antioxidants

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Sulforaphane (SFN), which is a hydrolysis product from glucoraphanin, a compound found in cruciferous vegetables, has been studied for its potential health benefits, particularly in disease prevention and treatment. SFN has proven to be effective in combating different types of cancer by inhibiting the proliferation of tumors and triggering apoptosis. This dual action has been demonstrated to result in a reduction in tumor size and an enhancement of survival rates in animal models. SFN has also shown antidiabetic and anti-obesity effects, improving glucose tolerance and reducing fat accumulation. SFN’s ability to activate Nrf2, a transcription factor regulating oxidative stress and inflammation in cells, is a primary mechanism behind its anticancerogenic and antidiabetic effects. Its antioxidant, anti-inflammatory, and anti-apoptotic properties are also suggested to provide beneficial effects against neurodegenerative diseases. The potential health benefits of SFN have led to increased interest in its use as a dietary supplement or adjunct to chemotherapy, but there are insufficient data on its efficacy and optimal doses, as well as its safety. This review aims to present and discuss SFN’s potential in treating various diseases, such as cancer, diabetes, cardiovascular diseases, obesity, and neurodegenerative diseases, focusing on its mechanisms of action. It also summarizes studies on the pharmacological and toxicological potential of SFN in in vitro and animal models and explores its protective role against toxic compounds through in vitro and animal studies.

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Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway

Zheng,

Xu,

Mao

et al. 2024

Biomedicine & Pharmacotherapy

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Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ

Cited by 7 publications

References 22 publications

Porous magnetic Silica nanoparticles loaded with sulforaphane mitigate myocardial infarction injury through upregulating HSP70

Porous magnetic Silica nanoparticles loaded with sulforaphane mitigate myocardial infarction injury through upregulating HSP70

Sulforaphane—A Compound with Potential Health Benefits for Disease Prevention and Treatment: Insights from Pharmacological and Toxicological Experimental Studies

Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway

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