Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

“…In another 4-week study including 40 individuals with hypertension found that daily ingestion of 10 g dried broccoli sprouts did not improve endothelial function (Christiansen et al, 2010). Conversely, although statistically non-significant (p 0.05), a trend towards a ∼10% decrease in diastolic blood pressure was reported in pregnant women with preeclampsia during a recent dose escalation study of activated broccoli extract (equivalent to 32 or 64 mg sulforaphane), regardless of sulforaphane dose (Langston-Cox et al, 2021). A current randomized controlled crossover trial is investigating whether regular consumption of cruciferous vegetables results in short-term improvement in cardiometabolic measures, such as ambulatory blood pressure and glycemic control (Connolly et al, 2020).…”

Biochemical Characterization of a Novel Myrosinase Rmyr fromRahnella inusitatafor High-Level Preparation of Sulforaphene and Sulforaphane

“…Sulforaphane (4-methylsulfinylbutyl isothiocyanate) and sulforaphene (4-methylsulfinyl-3-butenyl isothiocyanate) are two of the most active ITCs. Sulforaphane can prevent a host of cancers, such as breast cancer, prostate cancer, and melanoma, as well as hypertension, diabetes, and neurological diseases, which has been investigated and verified clinically or in human epidemiological studies. − Compared to sulforaphane, sulforaphene has a double hydrogen bond in the alkyl chain . Many in vitro experiments have confirmed that sulforaphene can prevent some cancers, obesity, mental illness, and inflammatory bowel disease. − Moreover, the preventive and improved effects of sulforaphene on esophageal cancer, osteosarcoma, and cognitive impairments have been demonstrated via in vivo experiments in corresponding mice or rats models. ,, Therefore, both sulforaphane and sulforaphene have broad application prospects in functional food and pharmaceutical industries.…”

The H2S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells

“…Indeed, a large variety of botanicals present in food, or better dosed and administered as supplements, are endowed with interesting anti-inflammatory and antioxidant activities that could be used for the prevention of endothelial dysfunction derived from vascular inflammation. For example, dietary molecules that slowly release hydrogen sulfide (H 2 S), such as garlic polysulfides [4] or isothiocyanates from brassica vegetables [5], seem to be the most promising compounds with demonstrated pre-clinical mechanisms of action and epidemiological evidence [6]. Indeed, the gasotransmitter H 2 S, released by slow H 2 S-donors (such as isothiocyanates [7,8]), exhibits well-known antioxidant properties, which are mainly related to the activation of antioxidant pathways, such as the Nrf2/ARE (nuclear erythroid 2-related factor 2/antioxidant response element) axis [9].…”