Sulfonylureas: Physico-chemical Properties, Analytical Methods of Determination and Bioavailability

Ali, Syed Laik; Blume, Henning; Schug, Barbara

doi:10.1007/978-3-662-09127-2_5

Cited by 3 publications

(3 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The need for an analytical method to supplement direct analysis of specific herbicides as verification of ALS-inhibitor herbicides exposure, is due to the difficulties in analyzing for individual ALS-inhibitor herbicides directly in plant tissue (5). Most herbicide extractions from plants are labor intensive (2,3,5). For example, a typical extraction for Pursuit (imazethapyr) in potatoes requires a liquid/liquid extraction, solvent exchange, two solid-phase extractions, another solvent exchange, and then analysis by HPLC (13).…”

Section: Resultsmentioning

confidence: 99%

“…Sulfonylurea and imidazolines (examples of ALS-inhibitor) herbicide analyses on real world matrixes (2) is challenging (3), due in part to several of the positive chemical attributes of these types of herbicides. One characteristic is the potency of sulfonylurea and imidazolines; consequently, application rates of active ingredient (ai)/acre are very low (e.g., tribenuronmethyl recommended rate on cereal grains is ca.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Marker for ALS-Inhibitor Herbicides: 2-Aminobutyric Acid Proportional in Sub-Lethal Applications

Loper

Cobb

Anderson

2002

J. Agric. Food Chem.

View full text Add to dashboard Cite

A chemical profiling technique for sub-lethal acetolactate synthase (ALS)-inhibitor herbicides (e.g., sulfonylureas, imidazolines, triazolopyrimidine sulfonanilides, and pyrimidyloxy salicylic) was developed using 2-aminobutyric acid, and was found to be directly proportional to application rates in field studies on two varieties of potato plants. An uncomplicated, benign-by-design analytical method for the determination of 2-aminobutyric acid in plant tissue was developed. The method is simple, fast, and automated, entailing a water-trichloroacetic acid extraction followed by precolumn on-line derivatization using o-phthalaldehyde (OPA) solution and liquid chromatographic analyses. Use of reagents and chlorinated organic solvents, and generation of waste, are minimized as compared to other ALS-inhibitor herbicide analytical techniques. Recoveries for a series of fortified plant tissues ranged from 82 to 103%. Two 20-day field trials on two potato varieties, Russet Burbank and Shepody, were conducted during the 2000 and 2001 growing seasons. The study demonstrated that the 2-aminobutyric acid method is an excellent, selective chemical marker technique for ALS-inhibitor herbicides for real world plant matrixes.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Marker for ALS-Inhibitor Herbicides: 2-Aminobutyric Acid Proportional in Sub-Lethal Applications

Loper

Cobb

Anderson

2002

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Alternatively, they finally suggested glibenclamide may have been used to colour the V8 tablets blue to resemble Viagra tablets. Nevertheless, we may think this hypothesis is unlikely as glibenclamide powder is actually white [51]. Instead, we suggest a possible contamination of sildenafil supplements by glibenclamide powder, either accidental or by negligence.…”

Section: Clinical Consequencesmentioning

confidence: 90%

Drug adulteration of sexual enhancement supplements: a worldwide insidious public health threat

Yéléhé‐Okouma

Pape

Humbertjean

et al. 2021

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

Worldwide, the consumption of dietary supplements for the enhancement of sexual performance is common. Consumers are generally fond of these products because they often want to avoid drugs, preferring “natural” than “chemical” solutions. This is challenging, as many of these supplements labelled “herbal” or “natural” are actually adulterated with drugs, mainly phosphodiesterase‐5 inhibitors. This phenomenon is facilitated by fewer demanding regulations for marketing supplements. Thus, consumers may be widely exposed to serious adverse events, such as acute liver injury, kidney failure, pulmonary embolism, stroke or even death. We aim to warn physicians about this issue. This multidisciplinary review simultaneously deals with clinical consequences of this phenomenon, analytical toxicology and regulation. Indeed, after outlining this worldwide issue and highlighting that a drug‐adulterated dietary supplement is actually a falsified drug, we discuss its main contributing factors. Then, we describe some examples of adverse events of which a case of sildenafil–tadalafil‐induced ischaemic stroke that benefited medical care in our hospital. Furthermore, we present some means to avoid adulteration and discuss their limitations that may be explained by the heterogeneity of the regulation of dietary supplements between countries. Doing so, we point out the requirement of a global harmonization of this regulation for an efficient eradication of this public health threat. Meanwhile, dietary supplements should be considered adulterated until proven otherwise. Thus, we encourage physicians to investigate these products in the drug histories of their patients, especially when clinical conditions cannot be explained by classical aetiologies.

show abstract

The effect of dietary fibers on the absorption of oral hypoglycemic drugs: a systematic review of controlled trials

Costa

Castro

Estrela

et al. 2022

Int J Diabetes Dev Ctries

View full text Add to dashboard Cite

Sulfonylureas: Physico-chemical Properties, Analytical Methods of Determination and Bioavailability

Cited by 3 publications

References 102 publications

Chemical Marker for ALS-Inhibitor Herbicides: 2-Aminobutyric Acid Proportional in Sub-Lethal Applications

Chemical Marker for ALS-Inhibitor Herbicides: 2-Aminobutyric Acid Proportional in Sub-Lethal Applications

Drug adulteration of sexual enhancement supplements: a worldwide insidious public health threat

The effect of dietary fibers on the absorption of oral hypoglycemic drugs: a systematic review of controlled trials

Contact Info

Product

Resources

About