Sulfonamide Blood Levels and Serum Antibacterial Activity

Weinstein, Louis; Samet, Charles A.

doi:10.1001/archinte.1962.03620230240033

Cited by 14 publications

(8 citation statements)

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“…The present study confirms results previously reported from this laboratory (8,9) indicating that, for an individual serum specimen, the chemically assayed sulfonamide content and that determined by a twofold broth-dilution method may be widely divergent. This was found with all three sulfonamides studied and occurred despite a positive correlation for the group as a whole with each drug, with an r value as high as 0.825 for sulfisoxazole.…”

Section: Discussionsupporting

confidence: 90%

Serum Sulfonamide Concentration After Oral Administration: Comparison of Results of Chemical Assay with Two Bioassay Techniques

Berman

Barza

Weinstein

1972

Antimicrob Agents Chemother

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Sulfonamide concentrations were studied in 210 serum samples from 10 volunteers after ingestion of sulfacytine, sulfisoxazole, and sulfadiazine. Results obtained by chemical assay were compared with bioassay values determined by two techniques: twofold broth dilution and agar diffusion. Although the correlation for individual samples was rather poor for the twofold broth-dilution method, the agar-diffusion bioassay correlated well with chemical determinations. The agar-diffusion assay tended to “underread” the chemical assay by an amount characteristic of each drug.

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Section: Discussionsupporting

confidence: 90%

Serum Sulfonamide Concentration After Oral Administration: Comparison of Results of Chemical Assay with Two Bioassay Techniques

Berman

Barza

Weinstein

1972

Antimicrob Agents Chemother

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“…Prostatic secretion and interstitial fluid concentrations of a number of antimicrobial agents (including ampicillins, cephalosporins, erythromycin, trimethoprim and sulphamethoxazole) were compared with concurrent plasma concen- It must be borne in mind, however, that factors other than drug concentrations in the body fluids a t infection sites influence the effectiveness of antimicrobial agents (Weinstein and Samet 1962). These will include a drug's inherent capacity to inhibit a n invading organism, the immune response of the host, the presence of substances that inhibit the action of a drug, the degree to which a drug is protein-bound, the extent to which it conjugates with various compounds, and possibly the p H of the surrounding medium.…”

Section: Distributionmentioning

confidence: 99%

“…Plasma concentrations of antimicrobial agents are only indirectly related to their tissue distribution and concentration, but there is no more satisfactory general index of therapeutic concentration (Weinstein and Samet 1962). The data on dose ratelplasma 'concentration relationships of antimicrobial agents in dogs, although continuing to accrue, are still fragmentary for many drugs and non-existent for some.…”

Section: Relationships Of Dose Rate Of Drugs To Their Concentration Imentioning

confidence: 99%

Plasma concentration and disposition of antimicrobial agents in the dog

English¹

1983

Aust Veterinary J

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Although there is sufficient information on the pharmacology and therapeutic application of the antimicrobial drugs to permit their effective use, they are still often misused in canine practice. This paper collates the data on drug dose rate/plasma concentration relationships observed in dogs after the administration of specific members of the major antimicrobial drug groups and on the possible impact of drug disposition (distribution and elimination) on therapeutic effect. Some information gleaned from studies in other animal species is added.

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“…In veterinary practice, minimum sulphonamide plasma concentrations of 50 ,ug/ml are generally sought (Stewart & Paris, 1962; English & Roberts, 1979); however, since it has been shown in man that there is a poor correlation between plasma sulphonamide concentration and clinical response (Weinstein & Samet, 1962), efficacy may rest ultimately on clinical result. When trimethoprim, which is active at about one-twentieth the concentration of the sulphonamides (Finland & Kass, 1973), is used in combination, its plasma concentration should be in the order of 2.5 pg/rnl.…”

Section: In Clinical Practicementioning

confidence: 99%

Antimicrobial chemotherapy in the dog

English

Prescott

1983

J of Small Animal Practice

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The concept is expounded that, in canine practice, antimicrobial therapy normally should be based on the pharmacology of the drug employed and the therapeutic responses that have been observed to it, as well as a knowledge of the in vitro sensitivities of causal agents. In so doing, information is presented on the concentrations of antimicrobials found to be inhibitory to micro‐organisms by in vitro tests and following clinical use. Guide‐lines to therapy are related to body systems and organs infected and to Gram‐stain reactions of isolates; also presented are dose rates, routes of administration and some general considerations employed when using the antimicrobial drugs for systemic therapy in the dog.

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Sulfonamide Blood Levels and Serum Antibacterial Activity

Cited by 14 publications

References 1 publication

Serum Sulfonamide Concentration After Oral Administration: Comparison of Results of Chemical Assay with Two Bioassay Techniques

Serum Sulfonamide Concentration After Oral Administration: Comparison of Results of Chemical Assay with Two Bioassay Techniques

Plasma concentration and disposition of antimicrobial agents in the dog

Antimicrobial chemotherapy in the dog

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