Sulfinic acids from disulfides: l-[35S]Cysteinesulfinic acid

Weinstein, Catherine L.

doi:10.1016/0076-6879(87)43051-6

Cited by 8 publications

(1 citation statement)

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“…For example, Griffith and Weinstein (1987) have shown that cystine-S-dioxide decomposes to cysteine sulfinic acid, cystine (ratio 2:1) and small amounts of cysteine sulfonic acid under mildly alkaline conditions, hence providing a possible spontaneous detoxification pathway for disulfide-S-oxides. As a consequence, redox-disproportionation reactions are theoretically possible.…”

Section: Rss and Antioxidant Defencementioning

confidence: 99%

Reactive Sulfur Species: An Emerging Concept in Oxidative Stress

Giles

Jacob²

2002

Biological Chemistry

271

178

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The ingredients of oxidative stress include a variety of reactive species such as reactive oxygen and reactive nitrogen species (ROS, RNS). While sulfur is usually considered as part of cellular antioxidant systems there is mounting evidence that reactive sulfur species (RSS) with stressor properties similar to the ones found in ROS are formed under conditions of oxidative stress. Thiols as well as disulfides are easily oxidised to sulfur species with sulfur in higher oxidation states. Such agents include thiyl radicals, disulfides, sulfenic acids and disulfide-S-oxides. They rapidly oxidise and subsequently inhibit thiol-proteins and enzymes and can be considered as a separate class of oxidative stressors providing new antioxidant drug targets.

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Section: Rss and Antioxidant Defencementioning

confidence: 99%