Sulfidation of Alicyclic and Heterocyclic 1,3-Dicarbonyl Systems

A Simple, Convenient One‐Pot Synthesis of Dithio‐Carbamide Derivatives of Heterocyclic 1,3‐Dicarbonyl Systems

“…This and the known fungicidal and antiseptic activity of thiuram (tetramethylthiuram disulfide) and disulfiram (antabuse, tetraethylthiuram disulfide) prompted us to synthesize sulfenyl derivatives of 4‐hydroxy‐2,5‐pyranopyridones, 4‐hydroxy‐2‐pyridones, and 4‐hydroxy‐coumarins. Preliminary results relating to the sulfenylation of alicyclic 1,3‐dicarbonyl systems have been published as a lecture abstract .…”

“…The equimolar amount of the aliphatic tetraalkylthiuram disulfides is used for the sulfinylation. Aromatic thioethers are prepared by the reaction of 3‐chloro‐4‐hydroxy‐2‐pyridones or their 3‐phenyl‐iodonium yields . Oxidation of the aliphatic thioethers is not possible like the aromatic thioethers under similar reaction conditions.…”