Sulfation of minoxidil by human platelet sulfotransferase

Johnson, George; Baker, Carolyn A.

doi:10.1016/0009-8981(87)90322-6

Cited by 40 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sulphation of hydroxy groups has been described in human liver and in blood platelets. The hepatic sulphation of 2-naphthol (Pacifici et al, 1988) and ethinyloestradiol (Temellini et al, 1991) varies over a range of 5 and 7-fold, respectively, whereas, in platelets, the sulphation of 3-methoxy-4-hydroxyphenylglycol (Anderson et al, 1981) and minoxidil (Johnson & Baker, 1987) varies over a range of 15-fold. Sulphation at nitrogen atoms has received little attention although alkyl-and aryl-amines are N-sulphated in rat liver (Iwasaki et al, 1983(Iwasaki et al, , 1986Johnson et al, 1982;Ramaswamy & Jakoby, 1987). The (Iwasaki et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…This prompted us to characterize further the interindividual variability of DMI N-sulphation in human liver. Anderson et al (1981), Johnson & Baker (1987), Price et al (1988) and Van Loon & Weinshilboum (1984) isolated from normal ileum and colon at room temperature, within 15 min after resection of the organ, and stored immediately at -80°C. Specimens of kidney and lung were obtained from five patients within 15 min after resection of tissue for removal of a tumour.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interindividual variability in the N‐sulphation of desipramine in human liver and platelets.

Romiti

Giuliani

Pacifici

1992

Brit J Clinical Pharma

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interindividual variability in the N‐sulphation of desipramine in human liver and platelets.

Romiti

Giuliani

Pacifici

1992

Brit J Clinical Pharma

View full text Add to dashboard Cite

“…Minoxidil sulfation was determined by the method of Johnson and Baker (9). Isolation and characterization of sulfotransferase cDNAs were performed as described (6,10).…”

Section: Methodsmentioning

confidence: 99%

Characterization and Expression of Hepatic Sulfotransferase Involved in the Metabolism of N-Substituted Aryl Compounds

Yamazoe¹,

Ozawa²,

Nagata³

et al. 1994

Environmental Health Perspectives

View full text Add to dashboard Cite

An aryl sulfotransferase, whose cDNA was isolated from the rat liver library, was found to catalyze bioactivation of minoxidil through N-O-sulfation and N-sulfation of a carcinogenic heterocyclic amine, IQ, by expression in COS-1 cells. cDNA of a human ortholog also was isolated and characterized as a major minoxidil-activating enzyme in human liver. Another group of aryl sulfotransferases catalyzing O-sulfation of carcinogenic N-hydroxyarylamines was separated from livers of rats and humans. These sulfotransferases have been shown to possess similar functional properties and also to relate immunochemically with each other. Current understanding on the primary structure of these sulfotransferases also is discussed. -Environ Health Perspect 102(Suppl 6): 99-103 (1994)

show abstract

“…Превращение минок-сидила в миноксидил сульфат катализируется фер-ментами сульфотрансферазами. Миноксидил-суль-фотрансферазная активность была обнаружена в гомогенатах печени крыс, человека, тромбоцитах, в фолликулах вибрисс мышей и крыс, в их эпидер-мальных кератиноцитах и эпителиальном влагали-ще корня волоса, в ВФ -в скальпе короткохвостых макак [12,[14][15][16][17][18][19][20].…”

Section: как это работает?unclassified

Minoxidil: a final judgment or a hope?

Gadzhigoroeva¹

2016

Klin. dermatol. venerol.

View full text Add to dashboard Cite

ооо «Институт Красивых волос», Москва, Россия, 105082Миноксидил является базовым препаратом для наружной терапии андрогенетической алопеции у мужчин и женщин. Между тем отношение к миноксидилу неоднозначно как среди пациентов, так и среди врачей. недостаточное понимание этиологии разных форм потери волос, отсутствие ясности в механизмах интеракции миноксидила с клетками-мишенями, в особенности с клетками волосяного фолликула, а также специфичность реакции самих волос на ранних этапах лечения компрометирует действие препарата на волосы и организм человека в целом, ограничивая терапевтические возможности при лечении облысения, снижает комплаентность лечению у пациента. в статье приводится обзор научных исследований о стимулирующих механизмах миноксидила на рост волос, о клинической эффективности и преимуществе использования лекарственной формы препарата в виде пены при андрогенетической алопеции.Ключевые слова: миноксидил, пена миноксидил, андрогенетическая алопеция, лечение. Minoxidil: a final judgment or a hope?A.g. gADzHIgoRoEvA «Institute of nice Hair», Moscow, Russia, 105082Minoxidil is a basic drug for the topical treatment of androgenetic alopecia in males and females. Meanwhile, the attitude of both patients and medical professionals to minoxidil is controversial. Insufficient understanding of the etiology of various forms of hair loss, lack of clear understanding of the mechanisms of interaction between minoxidil and target cells, particularly the hair follicle cells, as well as specific reactions of the hair itself at the early stages of treatment, compromise drug effect on the hair and the entire human body, which results in limited therapeutic potential in treatment of hair loss and reduces patients' compliance. This article provides an overview of the research of stimulatory mechanisms of minoxidil on hair growth, clinical efficacy and benefits of the use of foam-like dosage form of the drug in patients with androgenetic alopecia.

show abstract

Sulfation of minoxidil by human platelet sulfotransferase

Cited by 40 publications

References 14 publications

Interindividual variability in the N‐sulphation of desipramine in human liver and platelets.

Interindividual variability in the N‐sulphation of desipramine in human liver and platelets.

Characterization and Expression of Hepatic Sulfotransferase Involved in the Metabolism of N-Substituted Aryl Compounds

Minoxidil: a final judgment or a hope?

Contact Info

Product

Resources

About