Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro

Yang, Xi; Gao, Xiang; Han, Fang; Tan, Renxiang

doi:10.1016/j.bbagen.2005.06.013

Cited by 89 publications

(51 citation statements)

References 42 publications

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“…Polysaccharide produced by the bacteria Rhizobium meliloti was effective in free-radical scavenging and antioxidative activity (Kishk and Al-Sayed 2007). Sulphation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 significantly increases its antioxidant activity (Yang et al 2005). Sulfated polysaccharides from marine algae are known to exhibit many biological and physiological activities including anticoagulant, antihyperlipidemic, antiviral, antitumor and antioxidant activity (Qi et al 2005;Zhao et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Isolation and antioxidant property of the extracellular polysaccharide from Rhodella reticulata

Chen

You

Huang

et al. 2009

World J Microbiol Biotechnol

107

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The extracellular polysaccharide from Rhodella reticulata was separated from the culture medium followed by concentration and ethanol precipitation, and purified by anion exchange chromatography on DEAE-Sepharose Fast Flow. This study compared the free radical-scavenging property and antioxidant activity with various treatments of crude extracellular polysaccharides of R. reticulata. The results showed that both the crude extracellular polysaccharide and deproteinized crude extracellular polysaccharide gave evidence of the free radical scavenging and antioxidant activity in a dose-dependent manner. The crude extracellular polysaccharide exhibited higher free radical scavenging capacity and better antioxidant activity than the various treatments of crude extracellular polysaccharide samples. The superoxide anion radical scavenging ability of various samples was significantly higher compared to standard antioxidant (a-tocopherol). These results indicate that the extracellular polysaccharide of R. reticulata is a potent natural antioxidant.

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Section: Introductionmentioning

confidence: 99%

Isolation and antioxidant property of the extracellular polysaccharide from Rhodella reticulata

Chen

You

Huang

et al. 2009

World J Microbiol Biotechnol

107

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“…Sulfation of the water-free extract was prepared according to Yang et al (2005) with some modification. Water-free extract (0.1 g) was suspended in 0.5 mL dry formamide, and the mixture was stirred at room temperature for 24 h in order to disperse it into the solvent.…”

Section: Preparation Of Sulfated Extractsmentioning

confidence: 99%

Comparative evaluation of Bacillus licheniformis 5A5 and Aloe variegata milk-clotting enzymes

Ahmed

Helmy

2012

Braz. J. Chem. Eng.

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“…Moreover, it has been well established that polysaccharides possesses strong antioxidant activity [37,38]. Additionally, it has been found that sulfation of the polysaccharides further increases its antioxidant capacity against various antioxidant systems in vitro [39]. In the present study, sulfated polysaccharides were found to exhibit potent antioxidant effect.…”

Section: Discussionmentioning

confidence: 81%

Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney

Josephine

Amudha

Veena

et al. 2007

Molecular Nutrition Food Res

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Sulfated polysaccharides from marine seaweeds are receiving continuous attention owing to their wide therapeutic applications and are known to inhibit free radical generation. It has been well known that mitochondria are the major sources as well as the target of free radicals. The renal tubules have high density of mitochondria and therefore show structural and functional defects in acute renal failure. Hence, the present study is designed to appraise the mitochondrial status during Cyclosporine A (CsA)-induced nephrotoxicity and the effect of sulfated polysaccharides over it. Sulfated polysaccharides (5 mg/kg body weight, subcutaneously) treatment significantly prevented the CsA-induced (25 mg/kg body weight, orally) mitochondrial damage. CsA-induced mitochondrial oxidative stress in rat kidney was evident from increased reactive oxygen species level, decreased antioxidant defense system, coupled with enhanced lipid peroxidation. Further, the activities of tricarboxylic acid cycle and electron transport chain enzymes were decreased in CsA-induced rats, along with a significant increase in the activities of urinary enzymes, thus indicating renal tubular injury. Ultrastructural changes were also in accord with the above aberrations. The above abnormalities were favorably modulated by sulfated polysaccharides supplementation, thus highlighting the significance of sulfated polysaccharides in preventing the renal mitochondrial dysfunction allied with CsA-provoked nephrotoxicity.

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Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro

Cited by 89 publications

References 42 publications

Isolation and antioxidant property of the extracellular polysaccharide from Rhodella reticulata

Isolation and antioxidant property of the extracellular polysaccharide from Rhodella reticulata

Comparative evaluation of Bacillus licheniformis 5A5 and Aloe variegata milk-clotting enzymes

Beneficial effects of sulfated polysaccharides from Sargassum wightii against mitochondrial alterations induced by Cyclosporine A in rat kidney

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