Sulfated vizantin inhibits biofilm maturation by <i>Streptococcus mutans</i>

Oda, Masataka; Kurosawa, Mie; Yamamoto, Hirofumi; Domon, Hisanori; Takenaka, Shoji; Ohsumi, Tatsuya; Maekawa, Tomoki; Yamasaki, Naoto; Furue, Yui; Terao, Yutaka

doi:10.1111/1348-0421.12797

Cited by 4 publications

(6 citation statements)

References 37 publications

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“…Oral antibiotics specifically directed against oral caries can disrupt and destroy the signaling systems of pathogenic bacteria (Cui et al, 2019). For example, sulfated vizantin inhibits the extracellular release of cell-free glucosyltransferase, enhances the accumulation of cell-associated glucosyltransferase, and inhibits the maturation of S. mutans biofilms (Oda et al, 2020). Walkmycin C inhibits the biofilm formation and acid resistance of S. mutans (Eguchi et al, 2011).…”

Section: Interventions Targeting Oral Diseases Caused By Oral Pathoge...mentioning

confidence: 99%

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

et al. 2022

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The human oral cavity provides a habitat for oral microbial communities. The complexity of its anatomical structure, its connectivity to the outside, and its moist environment contribute to the complexity and ecological site specificity of the microbiome colonized therein. Complex endogenous and exogenous factors affect the occurrence and development of the oral microbiota, and maintain it in a dynamic balance. The dysbiotic state, in which the microbial composition is altered and the microecological balance between host and microorganisms is disturbed, can lead to oral and even systemic diseases. In this review, we discuss the current research on the composition of the oral microbiota, the factors influencing it, and its relationships with common oral diseases. We focus on the specificity of the microbiota at different niches in the oral cavity, the communities of the oral microbiome, the mycobiome, and the virome within oral biofilms, and interventions targeting oral pathogens associated with disease. With these data, we aim to extend our understanding of oral microorganisms and provide new ideas for the clinical management of infectious oral diseases.

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Section: Interventions Targeting Oral Diseases Caused By Oral Pathoge...mentioning

confidence: 99%

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

et al. 2022

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“…Finally, after removing the ion-exchange resin, the mixture was subjected to SEC with Sephadex ® G-25 to give the desired 3. [26][27][28][29][30][31] However, the overall yield of 3 from vizantin was only 29%. Thus, we embarked on improving the synthesis method in more detail (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…In the previous in vivo assay, 0.1-1.0 mM suspensions of vizantin were used for injection. 25) Accordingly, 3 was dissolved in distilled water (DW) and saline over a wide range of concentrations from 3 µM. Figure 3 shows the solution states of 3 at concentrations >5.0 mM.…”

Section: Resultsmentioning

confidence: 99%

“…Focusing on the difference between LPS and vizantin, our research demonstrated that vizantin represses TNF-α production from THP-1 cells triggered by Escherichia (E.) coli LPS in a dose-dependent manner. 25) Furthermore, the simultaneous administration of vizantin and LPS to C57BL/6 mice significantly increased survival rate by comparison to a single administration of LPS. These promising experimental findings based on in vivo assays with mice exceeded our expectations.…”

Section: Introductionmentioning

confidence: 94%

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Development of a Water Soluble Self-assembling Analogue of Vizantin

Nakano,

Sakamoto,

Yamasaki

et al. 2024

CHEMICAL & PHARMACEUTICAL BULLETIN

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Vizantin, 6,6′-bis-O-(3-nonyldodecanoyl)-α,α′-trehalose, has been developed as a safe immunostimulator on the basis of a structure-activity relationship study with trehalose 6,6′-dicorynomycolate. Our recent study indicated that vizantin acts as an effective Toll-like receptor-4 (TLR4) partial agonist to reduce the lethality of an immune shock caused by lipopolysaccharide (LPS). However, because vizantin has low solubility in water, the aqueous solution used in in vivo assay systems settles out in tens of minutes. Here, vizantin was chemically modified in an attempt to facilitate the preparation of an aqueous solution of the drug. This paper describes the concise synthesis of a water-soluble vizantin analogue in which all the hydroxyl groups of the sugar unit were replaced by sulfates. The vizantin derivative displayed micelle-forming ability in water and potent TLR-4 partial agonist activity.

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“…In recent years, the application of naturally derived substances other than antibiotics has attracted attention for the control of bacterial infections 27–32 . In particular, excessive use of antibiotics to control indigenous bacteria, such as oral bacteria, should be avoided.…”

Section: Introductionmentioning

confidence: 99%

β‐Glycyrrhetinic acid inhibits the bacterial growth and biofilm formation by supragingival plaque commensals

Dewake

Sato

et al. 2021

Microbiology and Immunology

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β‐Glycyrrhetinic acid (BGA) is a natural antibacterial agent. Previous studies reported that BGA has antibacterial effects against several bacteria. This study evaluated the effects of BGA on the regulation of supragingival plaque bacteria. First, the minimum inhibitory concentrations (MICs) of BGA against oral bacteria were measured. Next, the minimum concentrations for inhibition of biofilm formation were evaluated against Streptococcus mutans and Streptococcus sobrinus, possessing insoluble glucan synthesis abilities. The MICs of biofilm formation by these bacteria ranged from 1/8 to 2× MIC. Furthermore, the inhibition effects of BGA against the coaggregation of Porphyromonas gingivalis and Streptococcus gordonii were evaluated. BGA at 32 or 64 μg/mL inhibited the coaggregation of these bacteria after a 30 min incubation. Lastly, the inhibition effects of BGA against human supragingival plaque bacteria were evaluated. Human supragingival plaque samples were obtained from 12 healthy donors. The inhibition effects of BGA against biofilm formation by these plaque bacteria were evaluated. Of 12 samples, the biofilm formation by 11 was significantly attenuated by 128–256 μg/mL of BGA. The number of colony forming units in these biofilms was also significantly attenuated. In conclusion, it was revealed that BGA inhibits the growth and biofilm formation of bacteria, furthermore, the same effect was confirmed with supragingival plaque bacteria. BGA is a good candidate for a natural agent that prevents the outbreak and progression of periodontal disease because it suppresses not only the growth and biofilm formation of bacteria, but also the coaggregation of P. gingivalis with plaque bacteria.

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Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans

Cited by 4 publications

References 37 publications

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

Development of a Water Soluble Self-assembling Analogue of Vizantin

β‐Glycyrrhetinic acid inhibits the bacterial growth and biofilm formation by supragingival plaque commensals

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