Sulfated polysaccharide from the green marine algae Caulerpa racemosa reduces experimental pain in the rat temporomandibular joint

Ribeiro, Natássia Albuquerque; Chaves, Hellíada Vasconcelos; Rivanor, Renata Line da Conceição; Val, Danielle Rocha do; Assis, Ellen Lima de; Silveira, Felipe Dantas; Gomes, Francisco Isaac Fernandes; Freitas, Hermany Capistrano; Vieira, Lorena Vasconcelos; Costa, Deiziane Viana da Silva; Brito, Gerly Anne de Castro; Bezerra, Mirna Marques; Benevídes, Norma Maria Barros

doi:10.1016/j.ijbiomac.2020.01.272

Cited by 16 publications

(8 citation statements)

References 45 publications

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“…Second, hypernociception in animal models requires different neurotransmitters and neuromodulators, such as nitric oxide (NO) and carbon monoxide (CO), which represent the NO/ cyclic guanosine monophosphate/protein kinase G/ATPsensitive potassium channel (NO/cGMP/PKG/K + ATP ) pathway and the heme oxygenases (HO)/CO/cGMP/PKG pathway, respectively, to regulate nociception. Gc-FI is dependent on NO and CO, whereas Cr only relies on the HO-1 pathway and its functionality not influenced by the integrity of NO (Ribeiro et al, 2020;Coura et al, 2017). Last, Gc-FI also depends on the activation of opioid receptors to exert its antinociceptive effect, which was also confirmed in SPs from S. filiformis (Araújo et al, 2017).…”

Section: Sps From Marine Algae-derived Productsmentioning

confidence: 62%

“…Formalin, as an agonist of transient receptor potential ankyrin subtype 1 protein (TRPA1), which is a nonselective cation channel expressed in pain-sensing neurons and a promiscuous chemical sensor involved in sensory hyperreactivity in visceral organs, has been used to establish a stable model for an orofacial nociception study (Coura et al, 2017;. Capsaicin, as a derivative from red pepper, binds to transient receptor potential cation channel subfamily V member 1 (TRPV1) to activate sensory terminals and stimulate burning pain after injection (Ribeiro et al, 2020). The nociception induced by serotonin is realized in a rather indirect way on primary neurons via the activation of sympathomimetic amines and the synthesis of prostaglandin (Ribeiro et al, 2020;Oliveira-Fusaro et al, 2012).…”

Section: Bioactive Compounds In Preclinical Studiesmentioning

confidence: 99%

“…Capsaicin, as a derivative from red pepper, binds to transient receptor potential cation channel subfamily V member 1 (TRPV1) to activate sensory terminals and stimulate burning pain after injection (Ribeiro et al, 2020). The nociception induced by serotonin is realized in a rather indirect way on primary neurons via the activation of sympathomimetic amines and the synthesis of prostaglandin (Ribeiro et al, 2020;Oliveira-Fusaro et al, 2012). Zymosan, a polysaccharide derived from yeast cell walls, could induce severe and erosive arthritis and severe pain once injected (do Val et al, 2014).…”

Section: Bioactive Compounds In Preclinical Studiesmentioning

confidence: 99%

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Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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Section: Sps From Marine Algae-derived Productsmentioning

confidence: 62%

Section: Bioactive Compounds In Preclinical Studiesmentioning

confidence: 99%

Section: Bioactive Compounds In Preclinical Studiesmentioning

confidence: 99%

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Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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“…C. chemnitzia were also known to occur in Bangladesh coastal waters (Bay of Bengal) (Abdullah et al, 2020). Recently sulfated polysaccharide of Caulerpa racemosa were positively evaluated for anti-inflamatory activities (Ribeiro et al, 2020). The extracts C. racemosa were also used as sun screens (Ersalina et al, 2020) and source of anti-bacterial compounds (Belkacemi et al, 2020).…”

Section: Dna Barcoding Chlorophytamentioning

confidence: 99%

Identifying seaweeds species of Chlorophyta, Phaeophyta and Rhodophyta using DNA barcodes

Prasanthi

PrasannaKumar

Annadurai

et al. 2020

Preprint

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Strengthening the DNA barcode database is important for a species level identification, which was lacking for seaweeds. We made an effort to collect and barcode seaweeds occurring along Southeast coast of India. We barcoded 31 seaweeds species belonging to 21 genera, 14 family, 12 order of 3 phyla (viz., Chlorophyta, Ochrophyta and Rhodophyta). We found 10 species in 3 phyla and 2 genera (Anthophycus and Chnoospora) of Ochrophyta were barcoded for the first time. Uncorrected p-distance calculated using K2P, nucleotide diversity and Tajima’s test statistics reveals highest values among the species of Chlorophyta. Over all K2P distance was 0.36. The present study revealed the potentiality of rbcL gene sequences in identification of all 3 phyla of seaweeds. We also found that the present barcode reference libraries (GenBank and BOLD) were insufficient in seaweeds identification and more efforts were needed for strengthening local seaweed barcode library to benefit rapids developing field such as environmental DNA barcoding. We also show that the constructed barcode library could aid various industrial experts involved in seaweed bio-resource exploration and taxonomy/non-taxonomic researches involved in climate, agriculture and epigenetics research in precise seaweed identification. Since the rise of modern high-throughput sequencing technologies is significantly altering bio-monitoring applications and surveys, reference datasets such as ours will become essential in ecosystem’s health assessment and monitoring.

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“…Caulerpa produces interesting metabolites, namely caulerpin, sulfated polysaccharides (SP), racemosin, alkaloids, xyloglucans and fatty acid derived products, which are highly desirable for commercial purposes, and are not fully commercially exploited yet [ 4 , 5 ]. Among these, SPs showed a remarkable pharmaceutical potential, making this class of molecule one of the most interesting compounds biosynthesized by Caulerpa [ 18 , 19 , 20 ]. SPs can be synthesized by different biosynthetic pathways, depending on the polysaccharide backbone [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic Characterization of Sulfotransferase Provides New Insights for the Exploitation of Sulfated Polysaccharides in Caulerpa

Landi¹,

Esposito²

2020

IJMS

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Caulerpa is an unusual algal genus from Caulerpaceae (Chlorophyta, Bryopsidales). Species from this family produce a wide range of metabolites suitable for biotechnology applications. Among these, sulfated polysaccharides (SPs) are often highly desirable for pharmaceutical and nutraceutical applications. Here, we provide a classification of sulfotransferases from Caulerpa; these important enzymes catalyze the nodal step for the biosynthesis of SPs. For this, we performed phylogenetic, genomic, expression analyses and prediction of the protein structure on sulfotransferases from Caulerpa. Sequences, domains and structures of sulfotransferases generally shared common characteristics with other plants and algae. However, we found an extensive duplication of sulfotransferase gene family, which is unique among the green algae. Expression analysis revealed specific transcript abundance in the pinnae and rachis of the alga. The unique genomic features could be utilized for the production of complex SPs, which require multiple and specific sulfation reactions. The expansion of this gene family in Caulerpaceae would have resulted in a number of proteins characterizing the unique SPs found in these algae. We provide a putative biosynthetic pathway of SPs, indicating the unique characteristics of this pathway in Caulerpa species. These data may help in the future selection of Caulerpa species for both commercial applications and genetic studies to improve the synthesis of valuable products from Caulerpa.

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Sulfated polysaccharide from the green marine algae Caulerpa racemosa reduces experimental pain in the rat temporomandibular joint

Cited by 16 publications

References 45 publications

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Identifying seaweeds species of Chlorophyta, Phaeophyta and Rhodophyta using DNA barcodes

Bioinformatic Characterization of Sulfotransferase Provides New Insights for the Exploitation of Sulfated Polysaccharides in Caulerpa

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