Sulfated polyborate-catalyzed efficient and expeditious synthesis of (un)symmetrical ureas and benzimidazolones

Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

“…1,4‐Dihyropyridines 9 were prepared by a three‐component reaction of aldehydes 1 , 1,3‐diketone or β ‐diketoester 3 , and ammonium acetate or ammonium carbonate in different media (Methods A‐V, Scheme , Table ) …”

Expeditious and efficient synthesis of Strecker’s α-aminonitriles catalyzed by sulfated polyborate

“…[47][48][49][50][51][52] Its easy preparation, mild acidity, eco-friendliness, and reusability have encouraged us to investigate its potential to catalyze many other useful organic transformations. Therefore, inspired by our previous finding, herein we report a rapid, efficient and green method for synthesis of α-aminonitriles via Strecker reaction using aldehyde, amine, and TMSCN in the presence of a sulfated polyborate as a recyclable catalyst under solvent-free conditions.…”

Design, Synthesis and Antitumor Activity Evaluation Research of Novel 2,4,6-Substituted Pyrimidine Derivatives

“…Urea has the capacity to exert various non-covalent interactions such as hydrogen bonding and dipole interaction which can improve the physicochemical property and the ability of binding to biomolecular targets. [13][14][15] Compound 1 exhibited the strongest activity (IC 50 ＝ 5.21±0.47 μmol/L against A549), effectively regulated the expression of apoptosis-and cell cycle-related proteins, and influenced the rapidly accelerated fibrosarcoma (Raf)/mitogenactivate extracellular signal-regulated kinase (MEK)/extracellular regulated protein kinases (ERK) pathway. [16] Sorafenib 5 with the aryl urea group, as a key pharmacophore, is a systemic agent approved for the treatment of Hepatocellular Carcinoma (HCC) with good tolerance and safety.…”