Sulfated glycosaminoglycans in bladder tissue and urine of rats after acute exposure to paraoxon and cyclophosphamide

Соболев, В. Е.; Jenkins, Richard O.; Гончаров, Н. В.

doi:10.1016/j.etp.2017.02.007

Cited by 15 publications

(8 citation statements)

References 33 publications

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“…It is presumed that the location of the parasite in the deeper mucosal layers may be to avoid direct contact with the urine at certain stages of their development. This results in recurrent urinary tract infections, interstitial cystitis, urolithiasis, and neoplastic changes (1,3,10,11,13,20,25).…”

Section: Discussionmentioning

confidence: 99%

“…The urothelium surface is normally resilient to the biochemical components of the urine, microorganisms, and toxins. The local protection of the mucosal cells includes the tight junctions of umbrella cells (physical barrier) (5,9), glycosaminoglycans (9,11), cytokeratin (12), uroplakins (Upk1a, Upk1b, Upk2, Upk3a and Upk3b), and numerous membrane receptors (9,13).…”

Section: Introductionmentioning

confidence: 99%

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Morphological Peculiarities of Parasitic (Trichosomoides crassicauda) Infection in Rat Urinary Bladder

Sikora

Lуndіn

Hyriavenko

et al. 2021

Macedonian Veterinary Review

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Trichosomoides crassicauda (T. crassicauda) is a parasite commonly localized in the urinary bladder (UB) of laboratory and wild rats. The presence of these helminths can influence the prediction of pathological changes in the UB. Therefore, the purpose of this research was to make a comprehensive study of the features of the morphological changes in the UB wall of white laboratory rats as a result of T. crassicauda infestation. The study was performed on male rats using histological (Hematoxyline-Eosin and Alcian Blue staining) and immunohistochemical (Ki-67, Hsp70, Hsp90α, CD3 and CD20) methods. T. crassicauda was detected in both urine and UB samples. Morphological changes were observed as disruption in urothelial cell stratification and insignificant proliferative and immune responses in the UB. Increased heat shock protein levels were observed which may suggest a natural body’s resistance to this parasite.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphological Peculiarities of Parasitic (Trichosomoides crassicauda) Infection in Rat Urinary Bladder

Sikora

Lуndіn

Hyriavenko

et al. 2021

Macedonian Veterinary Review

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“…We utilized two different animal models with normal and cystitis‐induced bladders to examine the effect of the anesthetic drug, lidocaine, released from the IUCs prepared in this study. The animal model with a cystitis‐induced bladder was prepared by intraperitoneal injection of 75 mg/kg CYP 3 days prior to IUC insertion 27 . As shown in Figure 2, we employed eight different groups ( n = 5 per group): NB: no treatment; normal bladder without treatment. NB: IUC; normal bladder implanted with the intact IUC. NB: PLGA_IUC; normal bladder implanted with the PLGA_IUC. NB: L_PLGA_IUC; normal bladder implanted with the L_PLGA_IUC. CYP: no treatment; cystitis‐induced bladder without treatment. CYP: IUC; Cystitis‐induced bladder implanted with the intact IUC. CYP: PLGA_IUC; cystitis‐induced bladder implanted with the PLGA_IUC. CYP: L_PLGA_IUC; cystitis‐induced bladder implanted with the L_PLGA_IUC. …”

Section: Methodsmentioning

confidence: 99%

“…We utilized two different animal models with normal and cystitis-induced bladders to examine the effect of the anesthetic drug, lidocaine, released from the IUCs prepared in this study. The animal model with a cystitis-induced bladder was prepared by intraperitoneal injection of 75 mg/kg CYP three days prior to IUC insertion (Sobolev, Jenkins, & Goncharov, 2017)…”

Section: Animalsmentioning

confidence: 99%

Indwelling urinary catheter assembled with lidocaine‐loaded polymeric strand for local sustained alleviation of bladder discomfort

Kim

Jang

Yoon

et al. 2021

Bioengineering & Transla Med

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“…One of the most serious and difficult to treat side effects of CP administration is HC, which is characterized by diffuse inflammation and hemorrhage of the bladder mucosa [5]. Different treatments have been tried, such as oral or intravesical pentosane polysulfate [6], cystoProtek treatment [7], and cyclosporine therapy [8], all of which had several side effects. However, researchers still need to discover natural agents that could ameliorate CP-induced oxidative injury of the urinary bladder [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of thymoquinone on cyclophosphamide-induced injury in the rat urinary bladder

et al. 2020

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Introduction: Cyclophosphamide (CP) is a chemotherapeutic agent used to treat neoplastic diseases, but its side effects include hemorrhagic cystitis. Thymoquinone (TQ) is an active ingredient of Nigella sativa with healing potential. This study examined the protective effect of TQ against CP-induced oxidative injury in rat urinary bladder. Material and methods: Sixty rats were divided into 6 equal groups: untreated control (group A), TQ-treated with 10 mg/kg/day TQ for 10 days (group B1), TQ-treated with 100 mg/kg/day TQ for 5 days (group B2), toxicity control where 100 mg/kg CP was administered for 2 days (group C), CP + TQ-treated with the same TQ treatment as group B1 and 100 mg/kg CP for 2 days (group D1), and CP + TQ-treated with the same TQ treatment as group B2 and 100 mg/kg CP for 2 days (group D2). Rat urinary bladders were assessed histopathologically via hematoxylin and eosin (H&E) and Masson's trichrome stains and were evaluated for oxidative stress and cell death markers. Results: CP demonstrated significant reduction in glutathione reductase, and increased malondialdehyde levels and protein carbonylation (both p < 0.05). CP also induced cell death as measured by caspase-3 activation. Pretreatment with TQ (group D2) reduced CP-induced oxidative stress and apoptosis. Conclusions: TQ may ameliorate CP-induced oxidative injury in rat urinary bladder, via its antioxidant and antiapoptotic effects.

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Sulfated glycosaminoglycans in bladder tissue and urine of rats after acute exposure to paraoxon and cyclophosphamide

Cited by 15 publications

References 33 publications

Morphological Peculiarities of Parasitic (Trichosomoides crassicauda) Infection in Rat Urinary Bladder

Morphological Peculiarities of Parasitic (Trichosomoides crassicauda) Infection in Rat Urinary Bladder

Indwelling urinary catheter assembled with lidocaine‐loaded polymeric strand for local sustained alleviation of bladder discomfort

Effect of thymoquinone on cyclophosphamide-induced injury in the rat urinary bladder

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