Sulfated cellulose thin films with antithrombin affinity

Abstract

Cellulose thin films were chemically modified by in situ sulfation to produce surfaces with anticoagulant characteristics. Two celluloses differing in their degree of polymerization (DP): CEL I (DP 215–240) and CEL II (DP 1300–1400) were tethered to maleic anhydride copolymer (MA) layers and subsequently exposed to SO3•NMe3 solutions at elevated temperature. The impact of the resulting sulfation on the physicochemical properties of the cellulose films was investigated with respect to film thickness, atomic composition, wettability and roughness. The sulfation was optimized to gain a maximal surface concentration of sulfate groups. The scavenging of antithrombin (AT) by the surfaces was determined to conclude on their potential anticoagulant properties

Characterization of Multilayer Anti-Fog Coatings

“…These data indicate that the PEMA coating was thinner than 4−6 nm, while taking into account the possible presence of porosity. This is in agreement with previous literature − in which coating thicknesses ranging from 4 to 8 nm were obtained from spin coating PEMA polymer solutions with concentrations similar to those used in the present study. These ARXPS data warranted further characterization of the thickness and morphology of the anti-fog coating.…”

Semi-alicyclic polyimides as potential membrane oxygenators: Rheological implications on film processing, morphology and blood compatibility

“…Therefore, many efforts have been devoted to establish the ideal material characteristics in terms of platelet activation, blood coagulation ability or bacterial attachment. Literature survey on this subject indicates that there are several types of polymer structures that could fulfill the basic requirements for hemocompatibility, such as poly(ethylene terephthalate) [5], polyacrylonitrile [6], modified cellulose [7], polydimethylsiloxane [8], and polyurethane [9]. In the past years, another class of polymers emerged as bio-and hemocompatible materials, namely polyimides (PIs) [10].…”

Non-Resorbable Nanocomposite Membranes for Guided Bone Regeneration Based on Polysulfone-Quartz Fiber Grafted with Nano-TiO2

“…Membranes and membrane processes constitute the high technology field in which polymers have capitalized on their entire mechanical, thermal, chemical and economical potential. Starting from biopolymers and artificial polymers (cellulose and derivatives) [5,6,7], the membranes were able to develop through technopolymers (polysulfones [8], polyamides [9], polyimides [10], polyetherketones [11]) with a higher physicochemical resistance, especially to oxidative degradation and biodegradation [8,9,10,11]. At the same time, special polymers (polyoxazoles [12], polylactones and polylactams [13,14,15], fluorinated polymers [16], and polycrownethers [17]) contributed decisively to the development of the most advanced membranes in industrial processes: Gas separation, pervaporation, pertraction, ion exchange, chiral resolution, and combustion cells.…”