Sulfated and sulfonated polymers are able to solubilize efficiently the protein aggregates of different nature

Aggregative protein–polyelectrolyte complex for high-concentration formulation of protein drugs

“…Polyelectrolytes, charged linear polymers, have great potential as protein stabilizers [22][23][24][25][26][27][28][29] and functionalizing agents [30][31][32][33]. As described below, polyelectrolytes bind to complementary charged proteins, resulting in the formation of a protein-polyelectrolyte complex (PPC).…”

Artificial chaperones based on thermoresponsive polymers recognize the unfolded state of the protein

“…Synthetic polyelectrolytes of different nature can be an efficient tool to protect proteins against aggregation and to reactivate protein from pre-formed aggregates [13,14]. Indeed, protein aggregation can be suppressed by addition of polyanion [15,16] or polycation [17] depending on the protein charge.…”

“…Linear [13] and dendrimer [18][19][20] polyelectrolytes were also suggested as a prospective way to treat amyloid aggregation. The protective power of the polyelectrolyte was shown to depend on the nature of the charged groups (sulfated and sulfonated polymers are more efficient than polyphosphates [21] and polycarboxylates [15]), amount of the hydrophobic groups in the polymer chain [22], and degree of polymerization [15,21].…”

Complexes between cationic pyridylphenylene dendrimers and ovine prion protein: do hydrophobic interactions matter?

“…Applications of synthetic macromolecules in biomedicine have received considerable attention. Despite numerous reports on applications of synthetic polyelectrolytes for this purpose, [1][2][3][4][5] polydispersity of synthetic polymers hampers studies of biomolecule-polymer complexes and makes the interpretation of the results difficult. The absence of full and unambiguous information on complexes does not allow one to predict their performance as diagnostic and therapeutic agents.…”