Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

Sehm, Tina; Fan, Zheng; Ghoochani, Ali; Rauh, Manfred; Engelhorn, Tobias; Minakaki, Georgia; Dörfler, Arnd; Klucken, Jochen; Buchfelder, Michael; Eyüpoglu, Ilker Y.; Savaskan, Nicolai Ε.

doi:10.18632/oncotarget.8651

Cited by 103 publications

(88 citation statements)

References 34 publications

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“…Cell cycle analysis was performed according to Sehm et al [32]. Briefly, cells were seeded on culture dishes and kept under standard conditions for 3 days.…”

Section: Methodsmentioning

confidence: 99%

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Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis

et al. 2016

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Taxanes target microtubules and are clinically established chemotherapeutic agents with proven efficacy in human cancers. Cabazitaxel (XRP-6258, Jevtana®) is a second generation semisynthetic taxane with high chemotherapeutic potential in prostate cancer. There, cabazitaxel can overcome docetaxel-resistant prostate cancer. Here, we tested the effects of cabazitaxel on glioma cells, and non-transformed cells such as neurons and astrocytes. Cabazitaxel operates highly toxic in various human glioma cells at nanomolar concentrations. In contrast, primary astrocytes and neurons are not affected by this agent. Cabazitaxel disrupts cytoskeletal F-actin fibers and induces apoptotic cell death in gliomas. Moreover, cabazitaxel displayed highest efficacy in inhibiting glioma cell migration and invasion. Here we demonstrate that cabazitaxel inhibited tumor migration already at 1 nM. We also tested cabazitaxel in the ex vivo VOGiM assay. Cabazitaxel stalled glioma growth and at the same time inhibited tumor-induced angiogenesis. In summary, we found that cabazitaxel operates as an apoptosis-inducing gliomatoxic agent with strongest effects on migration and invasive growth. Thus, our report uncovered cabazitaxel actions on gliomas and on the brain tumor microenvironment. These data reveal novel aspects for adjuvant approaches when applied to brain tumor patients.

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“…Cell cycle analysis was performed according to Sehm et al [32]. Briefly, cells were seeded on culture dishes and kept under standard conditions for 3 days.…”

Section: Methodsmentioning

confidence: 99%

“…Hence, cells were isolated, washed thrice in PBS and resuspended in hypolysis buffer containing 0.1% sodium citrate, 0.1% Triton X-100, and 100 g/ml RNAse A. Nuclei were then stained with 7AAD and analyzed by fluorescence-activated cell sorting (FACS) [32]. Cell cycle phases were analyzed with Cellsoft software.…”

Section: Methodsmentioning

confidence: 99%

Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis

et al. 2016

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“…It has been demonstrated that SAS can induce ferroptosis in a series of cancer cell lines (HT‐1080, Calu‐1, 143B, BJeLR, BJeHLT) . SAS has also been used as a combined therapy to potentiate the therapeutic efficacy of other chemotherapeutics against glioma (Figure D) …”

Section: Ferroptosis Inducers For Cancer Therapymentioning

confidence: 99%

Recent Progress in Ferroptosis Inducers for Cancer Therapy

et al. 2019

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Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis‐inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.

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“…It was also found that sulfasalazine inhibits the glutamate transporter xCT (SCL7a11, system Xc - , SXC) and induces ferroptotic cell death in glioma cells. [26–28] …”

Section: Small Molecules For Ferroptosis-based Cancer Therapymentioning

confidence: 99%

Emerging Strategies of Cancer Therapy Based on Ferroptosis

et al. 2018

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Ferroptosis, a new form of regulated cell death that is iron- and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy. However, the published ferroptosis-related reviews have mainly focused on the mechanisms and pathways of ferroptosis, which motivated this contribution to bridge the gap between biological significance and material design. Therefore, it is timely to summarize the previous efforts on the emerging strategies for inducing ferroptosis and shed light on future directions for using such a tool to fight against cancer. Here, the current strategies of cancer therapy based on ferroptosis will be elaborated, the design considerations and the advantages and limitations are highlighted, and finally a future perspective on this emerging field is given.

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Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

Cited by 103 publications

References 34 publications

Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis

Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Emerging Strategies of Cancer Therapy Based on Ferroptosis

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