Sulfadoxine-Pyrimethamine–Based Intermittent Preventive Treatment, Bed Net Use, and Antenatal Care during Pregnancy: Demographic Trends and Impact on the Health of Newborns in the Kassena Nankana District, Northeastern Ghana

Oduro, Abraham; Fryauff, David J.; Koram, Kwadwo A.; Rogers, William O.; Anto, Francis; Atuguba, Frank; Anyorigiya, Thomas; Adjuik, Martin; Ansah, Patrick; Hodgson, Abraham; Nkrumah, Francis

doi:10.4269/ajtmh.2010.10-0066

Cited by 10 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of low birth weight as found in the current study seems not to have changed since an earlier report from the same health facility by Oduro and colleagues eight years ago [23]. Intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp - SP) is however known to be effective in reducing maternal malaria episodes, low birth weight, and preterm delivery [21, 24, 25].…”

Section: Discussionmentioning

confidence: 57%

Intermittent Preventive Treatment of Malaria in Pregnancy: Assessment of the Sulfadoxine-Pyrimethamine Three-Dose Policy on Birth Outcomes in Rural Northern Ghana

Anto

Agongo

Asoala

et al. 2019

Journal of Tropical Medicine

Self Cite

View full text Add to dashboard Cite

Background. Intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) decreases placental parasitaemia and improves birth outcomes. Currently, WHO recommends three or more doses of SP given during antenatal care (ANC), spaced one month apart after 16 weeks of gestation till delivery. This study determined the level of uptake of SP and its association with birth outcomes in rural northern Ghana. Methods. A survey was carried out at the War Memorial Hospital in Navrongo, Ghana, among mothers who had delivered within ten weeks and were seeking postnatal care. Data on time of first ANC, number of visits, receipt of IPTp-SP, and birth outcomes were extracted from the antenatal records of 254 mothers. Mothers were interviewed on their background characteristics and obstetric history. Chi-square tests and logistic regression were carried out to determine association between antenatal indicators, uptake of IPTp-SP, and birth outcomes using Stata version 13. Results. Uptake of three-five doses of SP was IPT3 =76.4%, IPT4 =37.3%, and IPT5 = 16.0%. Receipt of first dose of SP at 16, 17-24, and 25-36 weeks of gestation was 16.9%, 56.7%, and 26.4%, respectively. Taking the first dose of SP during the second trimester allowed for taking ≥3 doses of SP compared to taking the first dose during the third trimester (χ2 = 60.1, p<0.001). Women who made ≥4 visits were more likely to receive ≥3 doses of SP compared to those who made <4 visits (χ2 = 87.6, p<0.001). Women who received ≥ 3 doses of SP were more likely (OR = 3.3; 95% CI: 1.69-6.33) to give birth at term and also have normal weight babies (OR =4.0; 95% CI: 1.98-8.06). Conclusion. Uptake of three or more doses of SP contributed to improved pregnancy outcomes. Increased efforts towards improving early ANC attendance could increase uptake of SP and improve pregnancy outcomes.

show abstract

Section: Discussionmentioning

confidence: 57%

Intermittent Preventive Treatment of Malaria in Pregnancy: Assessment of the Sulfadoxine-Pyrimethamine Three-Dose Policy on Birth Outcomes in Rural Northern Ghana

Anto

Agongo

Asoala

et al. 2019

Journal of Tropical Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similar finding has been reported by Brabin et al 30 Non use of ITNs was found to be significant independent risk factor for fetal anaemia in this study (P = 0.01) This is due to increased risk of placental parasitaemia associated with non-use of ITNs. 23 Placental malaria was significantly associated with low birth weight in this study. The malaria parasites either directly cause mechanical compromise of placental circulation via widespread trophoblast membrane thickening, increased fibrinoid necrosis and cytotrophoblast prominence or indirectly interfere with placental function and induce pathological lesions.…”

Section: Discussionmentioning

confidence: 62%

Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

et al. 2015

View full text Add to dashboard Cite

Background: Malaria is the most common human parasitic disease and continues to be a complex and overwhelming global health problem, especially in sub-Saharan Africa. Placental malaria, one of the major features of malaria in pregnancy has been associated with serious adverse health consequences to both the mother and her fetus. Objective: This study sought to determine the prevalence of maternal, cord, and placental malarial parasitaemia at parturition, the association between maternal and placental parasitaemia, and also the association between placental parasitaemia and pregnancy outcomes. Materials and Methods: A descriptive cross-sectional design was used to study 330 pregnant women selected by the systematic random sampling technique as they presented in the labour ward of University of Uyo Teaching Hospital, Uyo between April, 2012 and September, 2012. Pre-delivery, maternal peripheral blood was taken for malaria parasite (MP) and packed cell volume (PCV). Post delivery, cord blood was taken for MP and PCV estimation while placental blood was examined for MP. Neonatal demographic and clinical characteristics were also obtained. The data was analyzed using SPSS version 17. Level of statistical significance was set at P less than 0.05 (P < 0.05). Results: The mean age of the respondents was 28.8 ± 4.4 years. The prevalence of maternal, cord, and placental parasitaemia were 30.3%, 14.8% and 18.2% respectively. There was a strong correlation between maternal parasitaemia and placental parasitaemia (rho = 0.75, P< 0.001). Also, a significant linear association between cord parasitaemia and placental malaria (rho = 0.87, p< 0.001) was found. Placental malaria predisposed to low birth weight (OR 1.01{95%CI 1.001 – 1.02}, p = 0.04) and fetal anaemia (OR 1.02{95%CI 1.01 – 1.03}, p < 0.001. Conclusion: There is a relatively high prevalence of placental parasitaemia at parturition. Placental malaria is associated with adverse pregnancy outcomes such as low birth weight, fetal anaemia and cord parasitaemia. Proven strategies to prevent malaria in pregnancy such as use of ITNs and IPT and free antenatal care should be intensified to curb this deadly but preventable disease.DOI: http://dx.doi.org/10.3126/ajms.v6i6.12401Asian Journal of Medical Sciences Vol.6(6) 2015 53-59

show abstract

“…The WHO goal of four ANC visits was met by more than 70% of the interviewed women. This is considerable when compared to West and East Africa [9,15-17]. Improvement of strategies for pregnant woman care can explain this high attendance.…”

Section: Discussionmentioning

confidence: 99%

Antenatal care visit attendance, intermittent preventive treatment and bed net use during pregnancy in Gabon

Bouyou-Akotet

Mawili-Mboumba

Kombila

2013

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundThe World Health Organization (WHO) recommends that intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and insecticide treated bed nets (ITNs) must be provided during antenatal care (ANC) visits for malaria prevention during pregnancy. The aim of this study was to determine the level of ANC attendance and its relationship with IPTp-SP and bed net coverage in Gabonese pregnant women.MethodsThis was a cross-sectional survey performed in 2011 in sentinel sites for malaria: two ANC units (Melen and Owendo) and one delivery unit (CHL). A validated structured questionnaire was used to collect the following data: age, parity, history of the current pregnancy including gestational age at the interview, number of ANC visits already performed, date of first visit, use of malaria preventive measure and details on IPTp-SP administration.ResultsDuring the study, 1030 women were interviewed, 735 at their ANC visit and 295 at the delivery. Their median age was 24[20–29] years and 21.0% were primigravidae. More than 70.0% attended their first ANC visit during the second trimester. Among the 442 women who were at the end of their pregnancy, 71.5% had a correct attendance, at least four ANC visits, most frequently women with no education and older women; IPTp-SP was offered to 84.1% of them and 57.4% received at least two doses. The number of SP doses was correlated to the number of ANC visits. Bed net coverage was 59.0%, not associated with ANC attendance. Among the women with correct ANC attendance, only 49.5% had a complete IPTp-SP course associated with bed net use during pregnancy. In the site where SP administration was supervised, 80% had four ANC visits and 97.4% received a full 2-dose course of IPTp-SP.ConclusionsDespite a high level of correct ANC attendance in Gabon, the goal of 80% of women with 2-dose IPTp-SP during pregnancy is not achieved. Evaluations, training of health workers, as well as surveys from other areas of the country are needed to further measure the implementation and the impact of these strategies.

show abstract

Sulfadoxine-Pyrimethamine–Based Intermittent Preventive Treatment, Bed Net Use, and Antenatal Care during Pregnancy: Demographic Trends and Impact on the Health of Newborns in the Kassena Nankana District, Northeastern Ghana

Cited by 10 publications

References 21 publications

Intermittent Preventive Treatment of Malaria in Pregnancy: Assessment of the Sulfadoxine-Pyrimethamine Three-Dose Policy on Birth Outcomes in Rural Northern Ghana

Intermittent Preventive Treatment of Malaria in Pregnancy: Assessment of the Sulfadoxine-Pyrimethamine Three-Dose Policy on Birth Outcomes in Rural Northern Ghana

Placental malarial parasitaemia and pregnancy outcome among parturients in a tertiary hospital in South- South Nigeria

Antenatal care visit attendance, intermittent preventive treatment and bed net use during pregnancy in Gabon

Contact Info

Product

Resources

About