Sulfadiazine in Murine Pertussis

Hornibrook, J. W.

doi:10.2307/4584062

Cited by 3 publications

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“…Winter ( 1953 ) also used this model to begin critical studies that would define the specific nature of protective immune responses. This model was further used to assess antimicrobial efficacy (Bradford and Wold 1939 ; Hornibrook 1942 ; Bradford et al 1944 ; Bradford and Day 1945 , 1949 ; Day and Bradford 1952 ; Gastal 1958 ).…”

Section: Non-primate Animal Models Of Pertussismentioning

confidence: 99%

Non-primate animal models for pertussis: back to the drawing board?

Cimolai

2022

Appl Microbiol Biotechnol

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Despite considerable progress in the understanding of clinical pertussis, the contemporary emergence of antimicrobial resistance for Bordetella pertussis and an evolution of concerns with acellular component vaccination have both sparked a renewed interest. Although simian models of infection best correlate with the observed attributes of human infection, several animal models have been used for decades and have positively contributed in many ways to the related science. Nevertheless, there is yet the lack of a reliable small animal model system that mimics the combination of infection genesis, variable upper and lower respiratory infection, systemic effects, infection resolution, and vaccine responses. This narrative review examines the history and attributes of non-primate animal models for pertussis and places context with the current use and needs. Emerging from the latter is the necessity for further such study to better create the optimal model of infection and vaccination with use of current molecular tools and a broader range of animal systems. Key points • Currently used and past non-primate animal models of B. pertussis infection often have unique and focused applications. • A non-primate animal model that consistently mimics human pertussis for the majority of key infection characteristics is lacking. • There remains ample opportunity for an improved non-primate animal model of pertussis with the use of current molecular biology tools and with further exploration of species not previously considered. Graphical abstract

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