Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees

Willbrand, Ethan H.; Maboudian, Samira A.; Kelly, Joseph P.; Parker, Benjamin J.; Foster, Brett L.; Weiner, Kevin S.

doi:10.1101/2023.02.06.527223

Cited by 2 publications

(1 citation statement)

References 96 publications

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“…As can been seen in Figure 2a, whether this dorsal recognition cluster was primarily located in the dPCC or dRSC varied from subject to subject, highlighting these subtle, but important, individual-differences in activation patterns. Additionally, in all but two of the subjects, a reliable recognition cluster was found in the middle of the PCC, around the splenial sulcus 39,40 . However, the exact location of this middle PCC recognition cluster was highly variable across individuals.…”

Section: Functional Neuroanatomy Of Item Recognition and Semantic Pro...mentioning

confidence: 83%

Dissociable contributions of the medial parietal cortex to recognition memory

Koslov,

Kable,

Foster

2023

Preprint

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Human neuroimaging studies of episodic memory retrieval routinely observe the engagement of specific cortical regions beyond the medial temporal lobe. Of these, medial parietal cortex (MPC) is of particular interest given its ubiquitous, and yet distinct, functional characteristics during different types of retrieval tasks. Specifically, while recognition memory and autobiographical recall tasks are both used to probe episodic retrieval, these paradigms consistently drive distinct patterns of response within MPC. This dissociation adds to growing evidence suggesting a common principle of functional organization across memory related brain structures, specifically regarding the control or content demands of memory-based decisions. To carefully examine this putative organization, we used a high-resolution fMRI dataset collected at ultra-high field (7T) while subjects performed thousands of recognition-memory trials to identify MPC regions responsive to recognition-decisions or semantic content of stimuli within and across individuals. We observed interleaving, though distinct, functional subregions of MPC where responses were sensitive to either recognition decisions or the semantic representation of stimuli, but rarely both. In addition, this functional dissociation within MPC was further accentuated by distinct profiles of connectivity bias with the hippocampus during task and rest. Finally, we show that recent observations of person and place selectivity within MPC reflect category specific responses from within identified semantic regions that are sensitive to mnemonic demands. Together, these data better account for how distinct patterns of MPC responses can occur as a result of task demands during episodic retrieval and may reflect a common principle of organization throughout hippocampal-neocortical memory systems.Significance statementMedial parietal cortex (MPC) plays a growing role in contemporary theories of episodic memory, as it is reliably observed in human neuroimaging to be engaged during tasks of recognition and retrieval. However, the spatial pattern of MPC engagement consistently differs across these putatively similar episodic memory tasks. Despite a large literature indicating that the MPC is important for episodic memory, there is little consensus about its specific role. Here, we employed ‘precision-neuroimaging’ to identify dissociable interleaving MPC subregions, where activity reflected either memory-based decision-making or stimulus content. This dissociation within MPC provides a better understanding for how retrieval demands shape response patterns and speaks to growing evidence for a common principle of organization across memory structures of the human brain.

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Section: Functional Neuroanatomy Of Item Recognition and Semantic Pro...mentioning

confidence: 83%

Dissociable contributions of the medial parietal cortex to recognition memory

Koslov,

Kable,

Foster

2023

Preprint

Self Cite

View full text Add to dashboard Cite

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The spatiotemporal dynamics of semantic integration in the human brain

Murphy,

Forseth,

Donos

et al. 2023

Nat Commun

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Language depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations of spatiotemporal resolution have previously rendered it difficult to isolate processes involved in semantic integration. We utilized intracranial recordings in epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential to a common object. Semantically referential sentences enabled high frequency broadband gamma activation (70–150 Hz) of the inferior frontal sulcus (IFS), medial parietal cortex, orbitofrontal cortex (OFC) and medial temporal lobe in the left, language-dominant hemisphere. IFS, OFC and posterior middle temporal gyrus activity was modulated by the semantic coherence of non-referential sentences, exposing semantic effects that were independent of task-based referential status. Components of this network, alongside posterior superior temporal sulcus, were engaged for referential sentences that did not clearly reduce the lexical search space by the final word. These results indicate the existence of complementary cortical mosaics for semantic integration in posterior temporal and inferior frontal cortex.

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Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees

Cited by 2 publications

References 96 publications

Dissociable contributions of the medial parietal cortex to recognition memory

Dissociable contributions of the medial parietal cortex to recognition memory

The spatiotemporal dynamics of semantic integration in the human brain

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