Suizidgedanken, Angst und Depression bei erwachsenen Neurodermitikern

Dieris-Hirche, Jan; Gieler, Uwe; Kupfer, J.; Milch, Wolfgang

doi:10.1007/s00105-009-1744-y

Cited by 58 publications

(17 citation statements)

References 25 publications

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“…Using a population-based sample from the U.S., Yang and colleagues found an increased likelihood of a depressive disorder in adults with AD (OR>2.0.) and a controlled study from Germany found increased rates of anxiety, depression, and suicidal ideation in adults with AD that correlated with disease severity [110-111]. Our group recently confirmed the association between AD and other mental health disorders including anxiety, depression, conduct disorder, and autism in a large U.S. pediatric population [103].…”

Section: Mental Healthsupporting

confidence: 55%

Comorbidity in Atopic Dermatitis

Simpson

2012

Curr Derm Rep

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The negative impact of atopic dermatitis (AD) often extends beyond the skin. Children with AD experience increased rates of infectious, mental health, and allergic diseases compared to their non-atopic peers. The mechanisms underlying these associations remain elusive. New insights from genetic and epidermal research pinpoint the skin barrier as a primary initiator of AD. Epicutaneous sensitization represents an intriguing new model which links a disrupted skin barrier to the later development of IgE-mediated diseases in patients with AD. Recent epidemiological studies have identified new comorbidities linked to AD as well, including several mental health disorders and obesity. This manuscript reviews the recent literature regarding both classic and newly described AD comorbidities.

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Section: Mental Healthsupporting

confidence: 55%

Comorbidity in Atopic Dermatitis

Simpson

2012

Curr Derm Rep

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“…26 A controlled study from Germany found increased rates of anxiety, depression, and suicidal ideation in adults with AD. 27 Three recent studies found an increased risk of autism in children with atopic diseases. 19,20,28 These studies of autism and AD were limited by the lumping of all atopic disease into one category, however.…”

Section: Discussionmentioning

confidence: 99%

Mental health comorbidity in patients with atopic dermatitis

Yaghmaie

Koudelka

Simpson

2013

Journal of Allergy and Clinical Immunology

395

323

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Background Recent data, primarily from Europe, suggest children with atopic dermatitis may be at increased risk of developing mental health disorders. Objective We aimed to quantify the mental health burden associated with pediatric atopic dermatitis in the United States. Methods A cross-sectional study design was used analyzing data from the 2007 National Survey of Children's Health – a survey reporting on the health status of 92,642 non-institutionalized children ages 0-17. The lifetime prevalence of various provider-diagnosed mental health conditions was calculated for those with and without a history of atopic dermatitis. Results The odds of having attention-deficit/hyperactivity disorder was significantly increased in children with atopic dermatitis compared to non-atopic dermatitis controls, OR 1.87 (95% CI 1.54, 2.27) even after controlling for known confounders. The adjusted odds ratios for depression, anxiety, conduct disorder, and autism were 1.81 (95% CI 1.33,2.46) , 1.77 (95% CI 1.36, 2.29), 1.87 (1.46, 2.39), and 3.04 (95% CI 2.13, 4.34), respectively, and these estimates were all statistically significant. A clear dose-dependent relationship was observed between the prevalence of a mental health disorder and the reported severity of the skin disease. Conclusions Our data reveal a striking association between mental health disorders and atopic dermatitis in the U.S. pediatric population. The severity of the skin disease alters the strength of the association. Prospective cohort studies are needed to verify these associations and to explore underlying mechanisms. Strategies to prevent atopic dermatitis or to aggressively treat early skin inflammation may modify the risk of developing mental health disorders in at-risk children.

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“…These effects might be reflected by a marked increase in suicidal ideation in patients with AD. [6][7][8] Despite the increasing worldwide incidence of AD, treatments are limited, with only 3 approved (depending on country) systemic therapeutic options for patients with severe disease who are inadequate responders to topical agents: oral corticosteroids, oral cyclosporin A (CsA), and UVA1/narrow-band UVB (NB-UVB) phototherapy. 9 These therapies are not uniformly effective, and their use is limited by toxicity (corticosteroids and CsA) or inconvenience (NB-UVB).…”

mentioning

confidence: 99%